Emerging Skin T-Cell Functions in Response to Environmental Insults

doi:10.1016/j.jid.2016.08.013

Review

. 2017 Feb;137(2):288-294.

doi: 10.1016/j.jid.2016.08.013. Epub 2016 Oct 23.

Emerging Skin T-Cell Functions in Response to Environmental Insults

Jutamas Suwanpradid¹, Zachary E Holcomb², Amanda S MacLeod³

Affiliations

¹ Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
² Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Duke University School of Medicine, Durham, North Carolina, USA.
³ Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA; Pinnell Center for Investigative Dermatology and Skin Disease Research Center, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: Amanda.MacLeod@duke.edu.

PMID: 27784595
PMCID: PMC5552043
DOI: 10.1016/j.jid.2016.08.013

Review

Emerging Skin T-Cell Functions in Response to Environmental Insults

Jutamas Suwanpradid et al. J Invest Dermatol. 2017 Feb.

. 2017 Feb;137(2):288-294.

doi: 10.1016/j.jid.2016.08.013. Epub 2016 Oct 23.

Authors

Jutamas Suwanpradid¹, Zachary E Holcomb², Amanda S MacLeod³

Affiliations

¹ Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
² Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Duke University School of Medicine, Durham, North Carolina, USA.
³ Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA; Pinnell Center for Investigative Dermatology and Skin Disease Research Center, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: Amanda.MacLeod@duke.edu.

PMID: 27784595
PMCID: PMC5552043
DOI: 10.1016/j.jid.2016.08.013

Abstract

Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

**Figure 1. Murine and human skin harbors T cells**
The illustration of diverse cutaneous T cell populations in the human and mouse. DETC, dendritic epidermal T cell; T_RM, tissue-resident memory T cell.

See this image and copyright information in PMC

Cited by

Hallmarks of environmental insults.
Peters A, Nawrot TS, Baccarelli AA. Peters A, et al. Cell. 2021 Mar 18;184(6):1455-1468. doi: 10.1016/j.cell.2021.01.043. Epub 2021 Mar 2. Cell. 2021. PMID: 33657411 Free PMC article. Review.
MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. Constantinides MG, et al. Science. 2019 Oct 25;366(6464):eaax6624. doi: 10.1126/science.aax6624. Science. 2019. PMID: 31649166 Free PMC article.
Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life.
Villafán H, Gutiérrez-Ospina G. Villafán H, et al. Brain Sci. 2023 Aug 30;13(9):1261. doi: 10.3390/brainsci13091261. Brain Sci. 2023. PMID: 37759864 Free PMC article.
Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research.
Youn C, Archer NK, Miller LS. Youn C, et al. J Invest Dermatol. 2020 Aug;140(8):1488-1497.e1. doi: 10.1016/j.jid.2020.04.012. Epub 2020 May 11. J Invest Dermatol. 2020. PMID: 32407714 Free PMC article.
Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration.
Wei JJ, Kim HS, Spencer CA, Brennan-Crispi D, Zheng Y, Johnson NM, Rosenbach M, Miller C, Leung DH, Cotsarelis G, Leung TH. Wei JJ, et al. Sci Immunol. 2020 Aug 28;5(50):eaba5683. doi: 10.1126/sciimmunol.aba5683. Sci Immunol. 2020. PMID: 32859683 Free PMC article.

See all "Cited by" articles

References

1. Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, et al. Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med. 2015;21:1272–9. - PMC - PubMed
1. Barbee SD, Woodward MJ, Turchinovich G, Mention JJ, Lewis JM, Boyden LM, et al. Skint-1 is a highly specific, unique selecting component for epidermal T cells. Proc Natl Acad Sci USA. 2011;108:3330–5. - PMC - PubMed
1. Barnes L, Dumas M, Juan M, Noblesse E, Tesniere A, Schnebert S, et al. γH2AX, an accurate marker that analyzes UV genotoxic effects on human keratinocytes and on human skin. Photochem Photobiol. 2010;86:933–41. - PubMed
1. Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg. 2005;31:674–86. discussion 86. - PubMed
1. Bennet CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation to topically applied hapten to T cells. J Immunol. 2007;179:6830–5. - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Molecular Biology Databases
- Mouse Genome Informatics (MGI)

[1] Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, et al. Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med. 2015;21:1272–9. - PMC - PubMed

[2] Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, et al. Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat Med. 2015;21:1272–9. - PMC - PubMed

[3] Barbee SD, Woodward MJ, Turchinovich G, Mention JJ, Lewis JM, Boyden LM, et al. Skint-1 is a highly specific, unique selecting component for epidermal T cells. Proc Natl Acad Sci USA. 2011;108:3330–5. - PMC - PubMed

[4] Barbee SD, Woodward MJ, Turchinovich G, Mention JJ, Lewis JM, Boyden LM, et al. Skint-1 is a highly specific, unique selecting component for epidermal T cells. Proc Natl Acad Sci USA. 2011;108:3330–5. - PMC - PubMed

[5] Barnes L, Dumas M, Juan M, Noblesse E, Tesniere A, Schnebert S, et al. γH2AX, an accurate marker that analyzes UV genotoxic effects on human keratinocytes and on human skin. Photochem Photobiol. 2010;86:933–41. - PubMed

[6] Barnes L, Dumas M, Juan M, Noblesse E, Tesniere A, Schnebert S, et al. γH2AX, an accurate marker that analyzes UV genotoxic effects on human keratinocytes and on human skin. Photochem Photobiol. 2010;86:933–41. - PubMed

[7] Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg. 2005;31:674–86. discussion 86. - PubMed

[8] Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg. 2005;31:674–86. discussion 86. - PubMed

[9] Bennet CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation to topically applied hapten to T cells. J Immunol. 2007;179:6830–5. - PubMed

[10] Bennet CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation to topically applied hapten to T cells. J Immunol. 2007;179:6830–5. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Emerging Skin T-Cell Functions in Response to Environmental Insults

Affiliations

Emerging Skin T-Cell Functions in Response to Environmental Insults

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases