Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct 6;13(10):989.
doi: 10.3390/ijerph13100989.

Influence of Bisphenol A on Type 2 Diabetes Mellitus

Donatella Paola Provvisiero  1 , Claudia Pivonello  2 , Giovanna Muscogiuri  3 , Mariarosaria Negri  4 , Cristina de Angelis  5 , Chiara Simeoli  6 , Rosario Pivonello  7 , Annamaria Colao  8
Affiliations
Review

Influence of Bisphenol A on Type 2 Diabetes Mellitus

Donatella Paola Provvisiero et al. Int J Environ Res Public Health. .

Abstract

Bisphenol A (BPA) is an organic synthetic compound employed to produce plastics and epoxy resins. It is used as a structural component in polycarbonate beverage bottles and as coating for metal surface in food containers and packaging. The adverse effects of BPA on human health are widely disputed. BPA has been recently associated with a wide variety of medical disorders and, in particular, it was identified as potential endocrine-disrupting compound with diabetogenic action. Most of the clinical observational studies in humans reveal a positive link between BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus. Clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate that BPA, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which BPA induces the impairment of insulin and glucagon secretion, triggers inhibition of cell growth and apoptosis, and acts on muscle, hepatic, and adipose cell function, triggering an insulin-resistant state. The current review summarizes the available evidences regarding the association between BPA and type 2 diabetes mellitus, focusing on both clinical and preclinical studies.

Keywords: bisphenol A; diabetes; insulin resistance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tabish S.A. Is Diabetes Becoming the Biggest Epidemic of the Twenty-first Century? Int. J. Health Sci. 2007;1:V–VIII. - PMC - PubMed
    1. Cho N.H., Whiting D., Forouhi N., Guariguata L., Hambleton I., Li R., Majeed A., Mbanya J.C., Montoya P.A., Motala A., et al. Idf Diabetes Atlas—7th Edition. International Diabetes Federation; Brussels, Belgium: 2015.
    1. American Diabetes Association-Standards of Medical Care in Diabetes 2016. Diabetes Care. 2016;39(Suppl. S1) doi: 10.2337/dc16-S001. - DOI
    1. Genetics and Diabetes. [(accessed on 19 September 2016)]. Available online: http://www.who.int/genomics/about/Diabetis-fin.pdf.
    1. Song Y., Chou E.L., Baecker A., You N.Y., Song Y., Sun Q., Liu S. Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis. J. Diabetes. 2016;8:516–532. doi: 10.1111/1753-0407.12325. - DOI - PubMed

LinkOut - more resources