Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

doi:10.1016/j.cancergen.2016.08.003

Review

. 2016 Sep;209(9):388-394.

doi: 10.1016/j.cancergen.2016.08.003. Epub 2016 Aug 10.

Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

Feifei Liu¹, Keith Dear², Lei Huang³, Li Liu⁴, Yun Shi⁴, Shaofa Nie⁴, Yisi Liu¹, Yuanan Lu⁵, Hao Xiang⁶

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China.
² Duke Kunshan University, No. 8 Duke Avenue, Kunshan 215316, China.
³ Zhoushan Entry-Exit Inspection and Quarantine Bureau of China, No. 555 Haijing Road, Zhoushan 316000, China.
⁴ Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
⁵ Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii at Manoa, 1960 East West Rd, Biomed Bldg, D105, Honolulu, HI 96822, USA.
⁶ Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China. Electronic address: xianghao@whu.edu.cn.

PMID: 27751356
DOI: 10.1016/j.cancergen.2016.08.003

Review

Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

Feifei Liu et al. Cancer Genet. 2016 Sep.

. 2016 Sep;209(9):388-394.

doi: 10.1016/j.cancergen.2016.08.003. Epub 2016 Aug 10.

Authors

Feifei Liu¹, Keith Dear², Lei Huang³, Li Liu⁴, Yun Shi⁴, Shaofa Nie⁴, Yisi Liu¹, Yuanan Lu⁵, Hao Xiang⁶

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China.
² Duke Kunshan University, No. 8 Duke Avenue, Kunshan 215316, China.
³ Zhoushan Entry-Exit Inspection and Quarantine Bureau of China, No. 555 Haijing Road, Zhoushan 316000, China.
⁴ Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
⁵ Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii at Manoa, 1960 East West Rd, Biomed Bldg, D105, Honolulu, HI 96822, USA.
⁶ Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China; Global Health Institute, Wuhan University, No. 115 Donghu Road, Wuhan 430071, China. Electronic address: xianghao@whu.edu.cn.

PMID: 27751356
DOI: 10.1016/j.cancergen.2016.08.003

Abstract

Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02-1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27-1.76, p <0.001; homozygote model: OR = 1.53, 95% CI: 1.28-1.83, p <0.001; allele model: OR = 1.21, 95% CI: 1.11-1.31, p <0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.

Keywords: Mir-27a; colorectal cancer; meta-analysis; polymorphism.

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Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

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Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

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