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Review
. 2016 Dec;12(12):768-776.
doi: 10.1038/nrneph.2016.147. Epub 2016 Oct 17.

Minimal change disease and idiopathic FSGS: manifestations of the same disease

Rutger J Maas  1 , Jeroen K Deegens  1 , Bart Smeets  2 , Marcus J Moeller  3 , Jack F Wetzels  1
Affiliations
Review

Minimal change disease and idiopathic FSGS: manifestations of the same disease

Rutger J Maas et al. Nat Rev Nephrol. 2016 Dec.

Abstract

Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and idiopathic FSGS are often considered to represent separate entities based on differences in their presenting characteristics, histology and outcomes, little evidence exists for this separation. We propose that MCD and idiopathic FSGS are different manifestations of the same progressive disease. The gradual development of FSGS in patients with non-remitting or relapsing INS has been well documented. Moreover, FSGS is the uniform result of substantial podocyte loss in animal models, and a common feature of virtually all progressive human glomerulopathies. As evidence suggests a common aetiology, the pathogenesis of MCD and idiopathic FSGS should be studied together. In clinical trials, idiopathic FSGS should be considered to represent an advanced stage of disease progression that is less likely to respond to treatment than the earlier stage of disease, which is usually defined as MCD.

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References

    1. BMC Nephrol. 2013 Feb 22;14:47 - PubMed
    1. Lab Invest. 1996 May;74(5):907-20 - PubMed
    1. Nephron. 1985;39(3):157-9 - PubMed
    1. Clin J Am Soc Nephrol. 2010 Nov;5(11):2115-21 - PubMed
    1. Kidney Int. 2014 Mar;85(3):636-40 - PubMed

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