Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov;12(11):645-657.
doi: 10.1038/nrrheum.2016.158. Epub 2016 Oct 13.

Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE

Thomas Dörner  1 , Peter E Lipsky  2
Affiliations
Review

Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE

Thomas Dörner et al. Nat Rev Rheumatol. 2016 Nov.

Abstract

New insights into the mechanisms of autoimmune diseases have been obtained not only from preclinical studies, but also from clinical trials of pan-B-cell-directed therapy. Overall, the results of these clinical trials suggest that more-specific approaches focusing on pathogenic B-cell functions, and perhaps sparing or even enhancing regulatory B-cell activity, might be attractive alternatives. Importantly, pathogenic B-cell subpopulations function within a network of cellular interactions, many of which might require additional interventions to restore immunologic balance and suppress autoimmune disease. Thus, approaches that simultaneously target innate immune cells as well as multiple nodes of T-cell and B-cell interactions might hold the promise of improved therapeutic efficacy. Interfering with B-cell intracellular signalling pathways, altering their intracellular metabolic pathways and perturbing transcription factors are additional options. This Review critically analyses these approaches, examines the role of cytokines and other functions of B-lineage cells separate from antibody secretion, and provides insights into the potential next generation of therapies targeting B-lineage cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arthritis Rheumatol. 2016 May;68(5):1210-21 - PubMed
    1. N Engl J Med. 2008 Feb 28;358(9):900-9 - PubMed
    1. Arthritis Rheum. 2011 Oct;63(10):3038-47 - PubMed
    1. Lupus. 2013 Dec;22(14):1489-503 - PubMed
    1. Arthritis Res Ther. 2009;11(5):247 - PubMed

MeSH terms

LinkOut - more resources