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Review
. 2017 Apr;23(2):225-234.
doi: 10.1007/s12253-016-0124-z. Epub 2016 Oct 8.

Clinical Applications of Next-Generation Sequencing in Cancer Diagnosis

Leila Sabour  1 , Maryam Sabour  1 , Saeid Ghorbian  2
Affiliations
Free article
Review

Clinical Applications of Next-Generation Sequencing in Cancer Diagnosis

Leila Sabour et al. Pathol Oncol Res. 2017 Apr.
Free article

Abstract

With the advancement and improvement of new sequencing technology, next-generation sequencing (NGS) has been applied increasingly in cancer genomics research fields. More recently, NGS has been adopted in clinical oncology to advance personalized treatment of cancer. NGS is utilized to novel diagnostic and rare cancer mutations, detection of translocations, inversions, insertions and deletions, detection of copy number variants, detect familial cancer mutation carriers, provide the molecular rationale for appropriate targeted, therapeutic and prognostic. NGS holds many advantages, such as the ability to fully sequence all types of mutations for a large number of genes (hundreds to thousands) and the sensitivity, speed in a single test at a relatively low cost compared to be other sequencing modalities. Here we described the technology, methods and applications that can be immediately considered and some of the challenges that lie ahead.

Keywords: Cancer; Clinical practice; Diagnosis; NGS; Next-generation sequencing.

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