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. 2016 Jul;43(4):256-267.
doi: 10.1159/000447458. Epub 2016 Jul 20.

Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?

Richard Schäfer  1 , Gabriele Spohn  1 , Patrick C Baer  2
Affiliations

Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?

Richard Schäfer et al. Transfus Med Hemother. 2016 Jul.

Abstract

Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the development of cell therapeutics in regenerative medicine. Featuring immunomodulatory potential as well as secreting a variety of trophic factors, MSCs showed remarkable therapeutic effects in numerous preclinical disease models. However, sustainable translation of MSC therapies to the clinic is hampered by heterogeneity of MSCs and non-standardized in vitro culture technologies. Moreover, potent MSC therapeutics require MSCs with maximum regenerative capacity. There is growing evidence that in vitro preconditioning strategies of MSCs can optimize their therapeutic potential. In the following we will discuss achievements and challenges of the development of MSC therapies in regenerative medicine highlighting specific in vitro preconditioning strategies prior to cell transplantation to increase their therapeutic efficacy.

Keywords: Bone marrow; Stem cell transplantation; Stem cells; Stroke.

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Figures

Fig. 1
Fig. 1
Mechanisms involved in the enhanced therapeutic potential of preconditioned MSCs.
See this image and copyright information in PMC

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