Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

doi:10.3390/ph3030600

Review

. 2010 Mar 11;3(3):600-620.

doi: 10.3390/ph3030600.

Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

Veerle Kersemans¹, Bart Cornelissen²

Affiliations

¹ Gray Institute for Radiation Oncology and Biology, University of Oxford/Old Road Campus Research Building, Off Roosevelt Drive, Churchill Hospital, Oxford OX3 7DQ, UK. veerle.kersemans@rob.ox.ac.uk.
² Gray Institute for Radiation Oncology and Biology, University of Oxford/Old Road Campus Research Building, Off Roosevelt Drive, Churchill Hospital, Oxford OX3 7DQ, UK. bart.cornelissen@rob.ox.ac.uk.

PMID: 27713270
PMCID: PMC4033971
DOI: 10.3390/ph3030600

Review

Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

Veerle Kersemans et al. Pharmaceuticals (Basel). 2010.

. 2010 Mar 11;3(3):600-620.

doi: 10.3390/ph3030600.

Authors

Veerle Kersemans¹, Bart Cornelissen²

Affiliations

¹ Gray Institute for Radiation Oncology and Biology, University of Oxford/Old Road Campus Research Building, Off Roosevelt Drive, Churchill Hospital, Oxford OX3 7DQ, UK. veerle.kersemans@rob.ox.ac.uk.
² Gray Institute for Radiation Oncology and Biology, University of Oxford/Old Road Campus Research Building, Off Roosevelt Drive, Churchill Hospital, Oxford OX3 7DQ, UK. bart.cornelissen@rob.ox.ac.uk.

PMID: 27713270
PMCID: PMC4033971
DOI: 10.3390/ph3030600

Abstract

Over the last couple of years, the number of original papers and reviews discussing various applications of cell penetrating peptides (CPPs) has grown exponentially. This is not remarkable since CPPs are capable of transporting the most varying cargo across cell membranes which is one of the biggest problems in drug delivery and targeted therapy. In this review, we focus on the use of CPPs and related peptides for delivery of imaging contrast agents and radionuclides to cells and tissues with the ultimate goal of in vivo molecular imaging and molecular radiotherapy of intracellular and even intranuclear targets.

Keywords: cell penetrating peptides; molecular imaging; radioimmunotherapy.

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Figures

**Figure 1**
A schematic overview of the various CPP-construct approaches for molecular imaging.

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References

1. Foerg C., Merkle H.P. On the biomedical promise of cell penetrating peptides: Limits versus prospects. J. Pharm. Sci. 2008;97:144–162. doi: 10.1002/jps.21117. - DOI - PubMed
1. Juliano R., Alam M.R., Dixit V., Kang H. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res. 2008;36:4158–4171. - PMC - PubMed
1. Kersemans V., Kersemans K., Cornelissen B. Cell penetrating peptides for in vivo molecular imaging applications. Curr. Pharm. Des. 2008;14:2415–2447. doi: 10.2174/138161208785777432. - DOI - PubMed
1. Torchilin V.P. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers. 2008;90:604–610. - PubMed
1. Vives E., Schmidt J., Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim. Biophys. Acta. 2008;1786:126–138. - PubMed

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[1] Foerg C., Merkle H.P. On the biomedical promise of cell penetrating peptides: Limits versus prospects. J. Pharm. Sci. 2008;97:144–162. doi: 10.1002/jps.21117. - DOI - PubMed

[2] Foerg C., Merkle H.P. On the biomedical promise of cell penetrating peptides: Limits versus prospects. J. Pharm. Sci. 2008;97:144–162. doi: 10.1002/jps.21117. - DOI - PubMed

[3] Juliano R., Alam M.R., Dixit V., Kang H. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res. 2008;36:4158–4171. - PMC - PubMed

[4] Juliano R., Alam M.R., Dixit V., Kang H. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res. 2008;36:4158–4171. - PMC - PubMed

[5] Kersemans V., Kersemans K., Cornelissen B. Cell penetrating peptides for in vivo molecular imaging applications. Curr. Pharm. Des. 2008;14:2415–2447. doi: 10.2174/138161208785777432. - DOI - PubMed

[6] Kersemans V., Kersemans K., Cornelissen B. Cell penetrating peptides for in vivo molecular imaging applications. Curr. Pharm. Des. 2008;14:2415–2447. doi: 10.2174/138161208785777432. - DOI - PubMed

[7] Torchilin V.P. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers. 2008;90:604–610. - PubMed

[8] Torchilin V.P. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers. 2008;90:604–610. - PubMed

[9] Vives E., Schmidt J., Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim. Biophys. Acta. 2008;1786:126–138. - PubMed

[10] Vives E., Schmidt J., Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim. Biophys. Acta. 2008;1786:126–138. - PubMed

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Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

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Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

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