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Review
. 2016:2016:4617983.
doi: 10.1155/2016/4617983. Epub 2016 Sep 6.

Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage

Paulo Henrique Rosado-de-Castro  1 , Felipe Gonçalves de Carvalho  2 , Gabriel Rodriguez de Freitas  3 , Rosalia Mendez-Otero  4 , Pedro Moreno Pimentel-Coelho  4
Affiliations
Review

Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage

Paulo Henrique Rosado-de-Castro et al. Stem Cells Int. 2016.

Abstract

Stroke is the second leading cause of mortality worldwide, causing millions of deaths annually, and is also a major cause of disability-adjusted life years. Hemorrhagic stroke accounts for approximately 10 to 27% of all cases and has a fatality rate of about 50% in the first 30 days, with limited treatment possibilities. In the past two decades, the therapeutic potential of bone marrow-derived cells (particularly mesenchymal stem cells and mononuclear cells) has been intensively investigated in preclinical models of different neurological diseases, including models of intracerebral hemorrhage and subarachnoid hemorrhage. More recently, clinical studies, most of them small, unblinded, and nonrandomized, have suggested that the therapy with bone marrow-derived cells is safe and feasible in patients with ischemic or hemorrhagic stroke. This review discusses the available evidence on the use of bone marrow-derived cells to treat hemorrhagic strokes. Distinctive properties of animal studies are analyzed, including study design, cell dose, administration route, therapeutic time window, and possible mechanisms of action. Furthermore, clinical trials are also reviewed and discussed, with the objective of improving future studies in the field.

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Figures

Figure 1
Figure 1
Charts summarizing the animal models (a), species (b), and sex of the animals (c) used in preclinical studies that have evaluated the potential of bone marrow-derived cells to treat hemorrhagic stroke.
Figure 2
Figure 2
Charts summarizing the type of bone marrow-derived cells (a), time of injection (b), and route of administration (c) in preclinical studies for hemorrhagic stroke.
Figure 3
Figure 3
Charts summarizing the timing of the latest behavioral test (a) and the minimal number of animals per experimental group (b) in preclinical studies that have evaluated the therapeutic potential of bone marrow-derived cells for hemorrhagic stroke.
See this image and copyright information in PMC

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