Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct;54(8):5973-5987.
doi: 10.1007/s12035-016-0131-9. Epub 2016 Sep 29.

PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury

I Paterniti  1 , M Campolo  1 , M Cordaro  1 , D Impellizzeri  1 , R Siracusa  1 , R Crupi  1 , E Esposito  1 , S Cuzzocrea  2   3
Affiliations

PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury

I Paterniti et al. Mol Neurobiol. 2017 Oct.

Retraction in

Abstract

Melatonin is the principal secretory product of the pineal gland, and its role as an immunomodulator is well established. Recent evidence shows that melatonin is a scavenger of oxyradicals and peroxynitrite and reduces the development of inflammation and tissue injury events associated with spinal cord trauma. Previous results suggest that peroxisome proliferator-activated receptor α (PPAR-α), a nuclear receptor protein that functions as a transcription factor activated by fatty acids, plays a role in control of secondary inflammatory process associated with spinal cord injury (SCI).With the aim to characterize the role of PPAR-α in melatonin-mediated anti-inflammatory activity, we tested the efficacy of melatonin (30 mg/kg) in an experimental model of spinal cord trauma, induced in mice, by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy, and comparing mice lacking PPAR-α (PPAR-α KO) with wild-type (WT) mice.The results obtained indicate that melatonin-mediated anti-inflammatory activity is weakened in PPAR-α KO mice, as compared to WT controls. In particular, melatonin was less effective in PPAR-α KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, pro-inflammatory cytokine expression, nuclear factor κB (NF-κB) activation, and inducible nitric oxide synthase (iNOS) expression. This study indicates that PPAR-α can contribute to the anti-inflammatory activity of melatonin in SCI.

Keywords: Melatonin; Myeloperoxidase; NF-κB; PPAR-α; iNOS.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Pineal Res. 2009 Jan;46(1):79-86 - PubMed
    1. J Chem Neuroanat. 2003 Jan;25(1):29-38 - PubMed
    1. Eur J Neurosci. 2000 Oct;12(10):3505-20 - PubMed
    1. J Cell Biochem. 1993 Dec;53(4):373-82 - PubMed
    1. Medicina (Kaunas). 2006;42(3):255-61 - PubMed

Publication types

MeSH terms

LinkOut - more resources