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Review
. 2016 Sep 21.
doi: 10.1007/s13277-016-5370-x. Online ahead of print.

The role of stem cells in benign tumors

Haiyan Qin  1   2 , Dongyu Bao  3   4 , Xin Tong  3 , Qingang Hu  3 , Guowen Sun  3 , Xiaofeng Huang  3
Affiliations
Free article
Review

The role of stem cells in benign tumors

Haiyan Qin et al. Tumour Biol. .
Free article

Abstract

As stem cells contribute to the development and homeostasis of normal adult tissues, malfunction of stem cells in self-renewal and differentiation has been associated with tumorigenesis. A growing number of evidences indicating that tumor initiating cells play a crucial role, not only in malignancies, but also in generation and development of benign tumors. Here we offer an overview of the identification and functional characterization of benign tumor initiating cells in several tissues and organs, which typically show capacities of uncontrolled self-renewal to fuel the tumor growth and abnormal differentiation to give rise to tumor heterogeneity. They may originate from alteration of normal stem cells, which confer the benign tumor initiating cells with different repertoire of "stemness". The plastic functions of benign tumor initiating cells are determined by niche regulation mediated via several signaling and epigenetic cues. Therefore, targeting stem cell function represents an important strategy for understanding the biology and management of benign tumors.

Keywords: Benign tumor; Differentiation; Self-renewal; Stem cells.

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References

    1. Am J Dermatopathol. 2004 Oct;26(5):379-84 - PubMed
    1. Science. 2012 Aug 10;337(6095):730-5 - PubMed
    1. Clin Neurosurg. 2001;48:306-19 - PubMed
    1. Blood. 2008 Dec 1;112(12 ):4646-54 - PubMed
    1. Am J Clin Pathol. 2000 Jul;114(1):123-6 - PubMed

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