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Review
. 2016 Aug 12;2(8):530-7.
doi: 10.1021/acsinfecdis.6b00094. Epub 2016 Jul 22.

Cryptosporidiosis Drug Discovery: Opportunities and Challenges

Ujjini H Manjunatha  1 , Alexander T Chao  1 , F Joel Leong  1 , Thierry T Diagana  1
Affiliations
Review

Cryptosporidiosis Drug Discovery: Opportunities and Challenges

Ujjini H Manjunatha et al. ACS Infect Dis. .

Abstract

The apicomplexan parasite Cryptosporidium is the second most important diarrheal pathogen causing life-threatening diarrhea in children, which is also associated with long-term growth faltering and cognitive deficiency. Cryptosporidiosis is a parasitic disease of public health concern caused by Cryptosporidium parvum and Cryptosporidium hominis. Currently, nitazoxanide is the only approved treatment for cryptosporidium infections. Unfortunately, it has limited efficacy in the most vulnerable patients, thus there is an urgent need for a safe and efficacious cryptosporidiosis drug. In this work, we present our current perspectives on the target product profile for novel cryptosporidiosis therapies and the perceived challenges and possible mitigation plans at different stages in the cryptosporidiosis drug discovery process.

Keywords: Cryptosporidium; cryptosporidiosis; diarrhea; drug discovery; target product profile.

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