Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;41(2):e19-e23.
doi: 10.1016/j.clinre.2016.07.007. Epub 2016 Sep 3.

Small colorectal cancers resembling submucosal tumor with massive submucosal invasion and lymph node metastasis: A report of two cases and review of the literature

Takahide Shinagawa  1 , Soichiro Ishihara  2 , Hiroaki Nozawa  2 , Koji Murono  2 , Takeshi Nishikawa  2 , Kensuke Otani  2 , Kazuhito Sasaki  2 , Koji Yasuda  2 , Toshiaki Tanaka  2 , Tomomichi Kiyomatsu  2 , Keisuke Hata  2 , Kazushige Kawai  2 , Hironori Yamaguchi  2 , Akimasa Hayashi  3 , Mariko Tanaka  3 , Tetsuo Ushiku  3 , Masashi Fukayama  3 , Toshiaki Watanabe  2
Affiliations
Review

Small colorectal cancers resembling submucosal tumor with massive submucosal invasion and lymph node metastasis: A report of two cases and review of the literature

Takahide Shinagawa et al. Clin Res Hepatol Gastroenterol. 2017 Mar.

Abstract

Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723). Tumors in the SMT-like group were significantly smaller in size compared with the control group; the median diameter measured 22mm vs. 37mm (P<0.01), respectively. Histologically, although the tumors in the SMT-like group were small in diameter, they almost all invaded into the submucosal (T1) or deeper layer (T2-4), and the rate of poorly differentiated adenocarcinoma or mucinous adenocarcinoma was significantly higher than that in the control group (48.6% vs. 7.7%; P<0.01). In the subgroup analysis of T1 tumors, the rate of lymphatic invasion in the SMT-like group was also significantly higher than that in the control group (43.8% vs. 15.4%; P<0.01). Carcinoma resembling SMT appears to be invasive and has a high risk of lymphatic invasion even if small in size. Therefore, surgical treatment with dissection of the regional lymph nodes might be necessary in cases with any signs of massive submucosal invasion.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources