The Hippo pathway in cellular reprogramming and regeneration of different organs
- PMID: 27592171
- DOI: 10.1016/j.ceb.2016.08.004
The Hippo pathway in cellular reprogramming and regeneration of different organs
Abstract
We have a limited ability to stimulate cells in damaged tissues to regenerate properly patterned and functional organs. Excitingly, however, recent work shows that experimental modulation of the Hippo pathway can promote the regeneration of several organs in mice. The Hippo pathway plays pivotal and specific roles in organ growth, cellular plasticity, and stem cell biology, which are all important for regeneration. In this review we survey and compare the effects of experimental manipulation of Hippo signaling in mouse on the development, homeostasis, and regeneration of the heart, liver, intestine, and other organs. We also discuss the potential of targeting the Hippo pathway as a therapeutic approach for regenerative medicine.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Similar articles
-
The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano.Stem Cells Dev. 2013 Aug 1;22(15):2174-85. doi: 10.1089/scd.2013.0006. Epub 2013 Apr 30. Stem Cells Dev. 2013. PMID: 23495768
-
The Hippo pathway in organ development, homeostasis, and regeneration.Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6. Curr Opin Cell Biol. 2017. PMID: 29316535 Free PMC article. Review.
-
The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart.Biomolecules. 2020 Jul 10;10(7):1024. doi: 10.3390/biom10071024. Biomolecules. 2020. PMID: 32664346 Free PMC article. Review.
-
The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming.Cell Rep. 2019 May 7;27(6):1637-1649.e6. doi: 10.1016/j.celrep.2019.04.047. Cell Rep. 2019. PMID: 31067451 Free PMC article.
-
Hippo signaling in epithelial stem cells.Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):39-45. doi: 10.1093/abbs/gmu111. Epub 2014 Dec 4. Acta Biochim Biophys Sin (Shanghai). 2015. PMID: 25476205 Review.
Cited by
-
Yes-Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis.Hepatology. 2020 Jul;72(1):72-87. doi: 10.1002/hep.30990. Epub 2020 Apr 11. Hepatology. 2020. PMID: 31610032 Free PMC article.
-
Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PLoS Biol. 2019. PMID: 30933975 Free PMC article.
-
Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis.Cancers (Basel). 2020 Aug 27;12(9):2438. doi: 10.3390/cancers12092438. Cancers (Basel). 2020. PMID: 32867200 Free PMC article. Review.
-
Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism.J Biol Chem. 2017 Sep 8;292(36):15002-15015. doi: 10.1074/jbc.M117.804005. Epub 2017 Jul 11. J Biol Chem. 2017. PMID: 28698384 Free PMC article.
-
Hippo Pathway: An Emerging Regulator of Craniofacial and Dental Development.J Dent Res. 2017 Oct;96(11):1229-1237. doi: 10.1177/0022034517719886. Epub 2017 Jul 12. J Dent Res. 2017. PMID: 28700256 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
