Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

doi:10.1038/onc.2016.253

Review

. 2017 Feb 16;36(7):877-884.

doi: 10.1038/onc.2016.253. Epub 2016 Aug 22.

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

F Wendler¹, R Favicchio², T Simon¹, C Alifrangis³, J Stebbing², G Giamas¹

Affiliations

¹ School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
² Imperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
³ Imperial College London, Department of Medical Oncology, NHS Trust, Hammersmith Hospital, London, UK.

PMID: 27546617
DOI: 10.1038/onc.2016.253

Review

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

F Wendler et al. Oncogene. 2017.

. 2017 Feb 16;36(7):877-884.

doi: 10.1038/onc.2016.253. Epub 2016 Aug 22.

Authors

F Wendler¹, R Favicchio², T Simon¹, C Alifrangis³, J Stebbing², G Giamas¹

Affiliations

¹ School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
² Imperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
³ Imperial College London, Department of Medical Oncology, NHS Trust, Hammersmith Hospital, London, UK.

PMID: 27546617
DOI: 10.1038/onc.2016.253

Abstract

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics.

PubMed Disclaimer

Cited by

Pathogenic Extracellular Vesicle (EV) Signaling in Amyotrophic Lateral Sclerosis (ALS).
Kim G, Chen X, Yang Y. Kim G, et al. Neurotherapeutics. 2022 Jul;19(4):1119-1132. doi: 10.1007/s13311-022-01232-9. Epub 2022 Apr 14. Neurotherapeutics. 2022. PMID: 35426061 Free PMC article. Review.
The potential applications of microparticles in the diagnosis, treatment, and prognosis of lung cancer.
Liu Y, Wang S, Xia H, Tan X, Song S, Zhang S, Meng D, Chen Q, Jin Y. Liu Y, et al. J Transl Med. 2022 Sep 5;20(1):404. doi: 10.1186/s12967-022-03599-x. J Transl Med. 2022. PMID: 36064415 Free PMC article. Review.
Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma.
Lin Y, Liao K, Miao Y, Qian Z, Fang Z, Yang X, Nie Q, Jiang G, Liu J, Yu Y, Wan J, Zhang X, Hu Y, Jiang J, Qiu Y. Lin Y, et al. J Natl Cancer Inst. 2020 Apr 1;112(4):343-355. doi: 10.1093/jnci/djz155. J Natl Cancer Inst. 2020. PMID: 31400201 Free PMC article.
HPV DNA Associates With Breast Cancer Malignancy and It Is Transferred to Breast Cancer Stromal Cells by Extracellular Vesicles.
De Carolis S, Storci G, Ceccarelli C, Savini C, Gallucci L, Sansone P, Santini D, Seracchioli R, Taffurelli M, Fabbri F, Romani F, Compagnone G, Giuliani C, Garagnani P, Bonafè M, Cricca M. De Carolis S, et al. Front Oncol. 2019 Sep 16;9:860. doi: 10.3389/fonc.2019.00860. eCollection 2019. Front Oncol. 2019. PMID: 31608222 Free PMC article.
Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma.
Palacios-Ferrer JL, García-Ortega MB, Gallardo-Gómez M, García MÁ, Díaz C, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias-Santiago S, Amezcua V, Peinado H, Vicente F, Pérez Del Palacio J, Marchal JA. Palacios-Ferrer JL, et al. Mol Oncol. 2021 Feb;15(2):407-428. doi: 10.1002/1878-0261.12823. Epub 2020 Nov 25. Mol Oncol. 2021. PMID: 33052601 Free PMC article.

See all "Cited by" articles

References

1. Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed
1. Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed
1. Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed
1. Cell. 2012 Dec 21;151(7):1542-56 - PubMed
1. Nature. 2016 Mar 3;531(7592):110-3 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program

[1] Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed

[2] Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed

[3] Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed

[4] Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed

[5] Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed

[6] Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed

[7] Cell. 2012 Dec 21;151(7):1542-56 - PubMed

[8] Cell. 2012 Dec 21;151(7):1542-56 - PubMed

[9] Nature. 2016 Mar 3;531(7592):110-3 - PubMed

[10] Nature. 2016 Mar 3;531(7592):110-3 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

Affiliations

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials