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Review
. 2016 Aug 1;7(4):229-39.
doi: 10.1515/bmc-2016-0017.

MicroRNAs in large herpesvirus DNA genomes: recent advances

Océane Sorel, Benjamin G Dewals
Free article
Review

MicroRNAs in large herpesvirus DNA genomes: recent advances

Océane Sorel et al. Biomol Concepts. .
Free article

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate gene expression. They alter mRNA translation through base-pair complementarity, leading to regulation of genes during both physiological and pathological processes. Viruses have evolved mechanisms to take advantage of the host cells to multiply and/or persist over the lifetime of the host. Herpesviridae are a large family of double-stranded DNA viruses that are associated with a number of important diseases, including lymphoproliferative diseases. Herpesviruses establish lifelong latent infections through modulation of the interface between the virus and its host. A number of reports have identified miRNAs in a very large number of human and animal herpesviruses suggesting that these short non-coding transcripts could play essential roles in herpesvirus biology. This review will specifically focus on the recent advances on the functions of herpesvirus miRNAs in infection and pathogenesis.

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