[Effectiveness and safety of intra-articular use of hyaluronic acid (Suplasyn I-Shot) in the treatment of knee osteoarthritis]
- PMID: 27526423
[Effectiveness and safety of intra-articular use of hyaluronic acid (Suplasyn I-Shot) in the treatment of knee osteoarthritis]
Abstract
Osteoarthritis (OA) is one of the leading causes of disability in the elderly. The changes in the lubricating properties of synovial fluid lead to significant pain and loss of function. Viscosupplementation, in which hyaluronic acid (HA) is injected into the knee joint, has evolved into an important part of our current therapeutic regimen in addressing the patient with knee pain due to OA. Intra-articular HA has proven to be an effective, safe, and tolerable treatment for symptomatic knee OA. In an effort to limit cardiovascular, gastrointestinal and renal safety concerns with COX-2 selective and nonselective NSAIDs and maximize HA efficacy, it is even proposed using HA earlier in the treatment paradigm for knee OA and also as part of a comprehensive treatment strategy. Our study reconfirmed effectiveness and safety of intra-articular use of hyaluronic acid (Suplasyn) in the treatment of knee osteoarthritis.
Similar articles
-
[Effectiveness and safety of intra-articular use of hyaluronic acid (Suplasyn) in the treatment of knee osteoarthritis].Przegl Lek. 2011;68(6):307-10. Przegl Lek. 2011. PMID: 22039667 Clinical Trial. Polish.
-
Assessment of knee function and biochemical parameters of articular fluid and peripheral blood in gonarthrosis patients following intra-articular administration of hyaluronic acid.Pol Orthop Traumatol. 2013 Aug 16;78:173-81. Pol Orthop Traumatol. 2013. PMID: 23959433 Clinical Trial.
-
Safety and efficacy of intra-articular injections of a combination of hyaluronic acid and mannitol (HAnOX-M) in patients with symptomatic knee osteoarthritis: Results of a double-blind, controlled, multicenter, randomized trial.Knee. 2016 Oct;23(5):842-8. doi: 10.1016/j.knee.2016.05.015. Epub 2016 Jun 25. Knee. 2016. PMID: 27353769 Clinical Trial.
-
Treating knee osteoarthritis with intra-articular hyaluronans.Curr Med Res Opin. 2008 Dec;24(12):3307-22. doi: 10.1185/03007990802490124. Curr Med Res Opin. 2008. PMID: 18954498 Review.
-
Is Local Viscosupplementation Injection Clinically Superior to Other Therapies in the Treatment of Osteoarthritis of the Knee: A Systematic Review of Overlapping Meta-analyses.Arthroscopy. 2015 Oct;31(10):2036-45.e14. doi: 10.1016/j.arthro.2015.03.030. Epub 2015 May 19. Arthroscopy. 2015. PMID: 25998016 Review.
Cited by
-
Intra-articular injection of N-acetylglucosamine and hyaluronic acid combined with PLGA scaffolds for osteochondral repair in rabbits.PLoS One. 2018 Dec 31;13(12):e0209747. doi: 10.1371/journal.pone.0209747. eCollection 2018. PLoS One. 2018. PMID: 30596714 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials