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Review
. 2015 Nov 20:4:183-91.
doi: 10.2147/OV.S66081. eCollection 2015.

Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy

Hiroshi Nakashima  1 , Tran Nguyen  1 , Ennio Antonio Chiocca  1
Affiliations
Review

Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy

Hiroshi Nakashima et al. Oncolytic Virother. .

Abstract

Histone deacetylase (HDAC) enzymes play a critical role in the epigenetic regulation of cellular functions and signaling pathways in many cancers. HDAC inhibitors (HDACi) have been validated for single use or in combination with other drugs in oncologic therapeutics. An even more novel combination therapy with HDACi is to use them with an oncolytic virus. HDACi may lead to an amplification of tumor-specific lytic effects by facilitating increased cycles of viral replication, but there may also be direct anticancer effects of the drug by itself. Here, we review the molecular mechanisms of anti-cancer effects of the combination of oncolytic viruses with HDACi.

Keywords: HDAC inhibitor; HSV-1; cancer; epigenetics; glioma; oncolytic virus.

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