Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement

doi:10.1111/risa.12683

Review

. 2016 Aug;36(8):1520-37.

doi: 10.1111/risa.12683. Epub 2016 Aug 11.

Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement

J A Shatkin¹, Kimberly J Ong¹, Christian Beaudrie², Amy J Clippinger³, Christine Ogilvie Hendren⁴, Lynne T Haber⁵, Myriam Hill⁶, Patricia Holden⁷, Alan J Kennedy⁸, Baram Kim⁹, Margaret MacDonell¹⁰, Christina M Powers¹¹, Monita Sharma³, Lorraine Sheremeta¹², Vicki Stone¹³, Yasir Sultan¹⁴, Audrey Turley¹⁵, Ronald H White¹⁶

Affiliations

¹ Vireo Advisors, Boston, MA, USA.
² Compass RM, Vancouver, CA, USA.
³ PETA International Science Consortium Ltd, London, UK.
⁴ Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC, USA.
⁵ TERA, Cincinnati, OH, USA.
⁶ Health Canada, Ottawa, Canada.
⁷ UC Santa Barbara, Bren School of Environmental Science & Management, ERI, and UC CEIN, University of California, Santa Barbara, CA, USA.
⁸ U.S. Army Engineer Research and Development Center, Environmental Laboratory, Vicksburg, MS, USA.
⁹ Independent, Somerville, MA, USA.
¹⁰ Argonne National Laboratory, Environmental Science Division, Argonne, IL, USA.
¹¹ U.S. Environmental Protection Agency, Office of Air and Radiation, Office of Transportation and Air Quality, Ann Arbor, MI, USA.
¹² Alberta Ingenuity Labs, Edmonton, Alberta, Canada.
¹³ John Muir Building Gait 1 Heriot-Watt University, Edinburgh, Scotland, UK.
¹⁴ Environment Canada, Gatineau, QC, Canada.
¹⁵ ICF International, Durham, NC, USA.
¹⁶ RH White Consultants, Silver Spring, MD, USA.

PMID: 27510619
DOI: 10.1111/risa.12683

Review

Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement

J A Shatkin et al. Risk Anal. 2016 Aug.

. 2016 Aug;36(8):1520-37.

doi: 10.1111/risa.12683. Epub 2016 Aug 11.

Authors

Affiliations

¹ Vireo Advisors, Boston, MA, USA.
² Compass RM, Vancouver, CA, USA.
³ PETA International Science Consortium Ltd, London, UK.
⁴ Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC, USA.
⁵ TERA, Cincinnati, OH, USA.
⁶ Health Canada, Ottawa, Canada.
⁷ UC Santa Barbara, Bren School of Environmental Science & Management, ERI, and UC CEIN, University of California, Santa Barbara, CA, USA.
⁸ U.S. Army Engineer Research and Development Center, Environmental Laboratory, Vicksburg, MS, USA.
⁹ Independent, Somerville, MA, USA.
¹⁰ Argonne National Laboratory, Environmental Science Division, Argonne, IL, USA.
¹¹ U.S. Environmental Protection Agency, Office of Air and Radiation, Office of Transportation and Air Quality, Ann Arbor, MI, USA.
¹² Alberta Ingenuity Labs, Edmonton, Alberta, Canada.
¹³ John Muir Building Gait 1 Heriot-Watt University, Edinburgh, Scotland, UK.
¹⁴ Environment Canada, Gatineau, QC, Canada.
¹⁵ ICF International, Durham, NC, USA.
¹⁶ RH White Consultants, Silver Spring, MD, USA.

PMID: 27510619
DOI: 10.1111/risa.12683

Abstract

The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

Keywords: Alternative testing strategies; expert workshop; nanomaterials; nanotoxicology; risk analysis.

PubMed Disclaimer

Cited by

Comparative, collaborative, and integrative risk governance for emerging technologies.
Linkov I, Trump BD, Anklam E, Berube D, Boisseasu P, Cummings C, Ferson S, Florin MV, Goldstein B, Hristozov D, Jensen KA, Katalagarianakis G, Kuzma J, Lambert JH, Malloy T, Malsch I, Marcomini A, Merad M, Palma-Oliveira J, Perkins E, Renn O, Seager T, Stone V, Vallero D, Vermeire T. Linkov I, et al. Environ Syst Decis. 2018 May 4;38(2):170-176. doi: 10.1007/s10669-018-9686-5. Environ Syst Decis. 2018. PMID: 37829286 Free PMC article.
U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials.
Petersen EJ, Ceger P, Allen DG, Coyle J, Derk R, Garcia-Reyero N, Gordon J, Kleinstreuer NC, Matheson J, McShan D, Nelson BC, Patri AK, Rice P, Rojanasakul L, Sasidharan A, Scarano L, Chang X. Petersen EJ, et al. ALTEX. 2022;39(2):183–206. doi: 10.14573/altex.2105041. Epub 2021 Dec 3. ALTEX. 2022. PMID: 34874455 Free PMC article.
A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment.
Halappanavar S, Ede JD, Mahapatra I, Krug HF, Kuempel ED, Lynch I, Vandebriel RJ, Shatkin JA. Halappanavar S, et al. Nanotoxicology. 2021 Apr;15(3):289-310. doi: 10.1080/17435390.2020.1851419. Epub 2020 Dec 14. Nanotoxicology. 2021. PMID: 33317378 Free PMC article.
Risk Analysis of Cellulose Nanomaterials by Inhalation: Current State of Science.
Ede JD, Ong KJ, Goergen M, Rudie A, Pomeroy-Carter CA, Shatkin JA. Ede JD, et al. Nanomaterials (Basel). 2019 Mar 2;9(3):337. doi: 10.3390/nano9030337. Nanomaterials (Basel). 2019. PMID: 30832338 Free PMC article. Review.
Characterizing risk assessments for the development of occupational exposure limits for engineered nanomaterials.
Schulte PA, Kuempel ED, Drew NM. Schulte PA, et al. Regul Toxicol Pharmacol. 2018 Jun;95:207-219. doi: 10.1016/j.yrtph.2018.03.018. Epub 2018 Mar 21. Regul Toxicol Pharmacol. 2018. PMID: 29574195 Free PMC article. Review.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Wiley
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement

Affiliations

Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical