Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
- PMID: 27503945
- DOI: 10.1042/CS20160005
Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
Abstract
The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may link accumulation of adipose tissue in obesity to metabolic diseases, although the underlying mechanisms are not completely understood. In the past decades, data from human studies and transgenic animal models strongly suggested correlative, but also causative associations between activation of proinflammatory pathways and insulin resistance. Particularly chronic inflammation in adipose tissue seems to play an important role in the development of obesity-related insulin resistance. On the other hand, adipose tissue inflammation has been shown to be essential for healthy adipose tissue expansion and remodelling. However, whether adipose tissue inflammation represents a consequence or a cause of impaired insulin sensitivity remains an open question. A better understanding of the molecular pathways linking excess adipose tissue storage to chronic inflammation and insulin resistance may provide the basis for the future development of anti-inflammatory treatment strategies to improve adverse metabolic consequences of obesity. In this review, potential mechanisms of adipose tissue inflammation and how adipose tissue inflammation may cause insulin resistance are discussed.
Keywords: adipocytes; adipokines; adipose tissue inflammation; adipose tissue macrophages; insulin resistance; obesity.
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
Similar articles
-
Adipose inflammation, insulin resistance, and cardiovascular disease.JPEN J Parenter Enteral Nutr. 2008 Nov-Dec;32(6):638-44. doi: 10.1177/0148607108325251. JPEN J Parenter Enteral Nutr. 2008. PMID: 18974244 Free PMC article. Review.
-
Do adipose tissue macrophages promote insulin resistance or adipose tissue remodelling in humans?Horm Mol Biol Clin Investig. 2014 Oct;20(1):3-13. doi: 10.1515/hmbci-2014-0036. Horm Mol Biol Clin Investig. 2014. PMID: 25460290 Review.
-
Obesity and cardiovascular disease: role of adipose tissue, inflammation, and the renin-angiotensin-aldosterone system.Horm Mol Biol Clin Investig. 2013 Sep;15(2):49-57. doi: 10.1515/hmbci-2013-0025. Horm Mol Biol Clin Investig. 2013. PMID: 25436732 Review.
-
Recent advances in the relationship between obesity, inflammation, and insulin resistance.Eur Cytokine Netw. 2006 Mar;17(1):4-12. Eur Cytokine Netw. 2006. PMID: 16613757 Review.
-
Macrophage recruitment in obese adipose tissue.Obes Rev. 2015 Feb;16(2):127-36. doi: 10.1111/obr.12242. Epub 2015 Jan 13. Obes Rev. 2015. PMID: 25586506 Free PMC article. Review.
Cited by
-
Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery.Oxid Med Cell Longev. 2019 Dec 6;2019:3940739. doi: 10.1155/2019/3940739. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31885787 Free PMC article. Review.
-
The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.Br J Pharmacol. 2019 Aug;176(15):2678-2690. doi: 10.1111/bph.14690. Epub 2019 Jun 20. Br J Pharmacol. 2019. PMID: 31012948 Free PMC article.
-
Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans.Sci Rep. 2018 Mar 16;8(1):4677. doi: 10.1038/s41598-018-22962-x. Sci Rep. 2018. PMID: 29549282 Free PMC article.
-
Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis.Nutrients. 2020 Feb 21;12(2):564. doi: 10.3390/nu12020564. Nutrients. 2020. PMID: 32098159 Free PMC article.
-
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273.Cells. 2020 Feb 2;9(2):343. doi: 10.3390/cells9020343. Cells. 2020. PMID: 32024237 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
