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. 2016 Aug 2;11(8):e0160415.
doi: 10.1371/journal.pone.0160415. eCollection 2016.

Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China

Jun Yao  1 , Bao-Jie Wang  1
Affiliations

Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China

Jun Yao et al. PLoS One. .

Abstract

In the present study, we investigated the genetic characteristics of 25 Y-chromosomal and 15 autosomal short tandem repeat (STR) loci in 305 unrelated Han Chinese male individuals from Liaoning Province using AmpFISTR® Yfiler® Plus and IdentifilerTM PCR amplification kits. Population comparison was performed between Liaoning Han population and different ethnic groups to better understand the genetic background of the Liaoning Han population. For Y-STR loci, the overall haplotype diversity was 0.9997 and the discrimination capacity was 0.9607. Gene diversity values ranged from 0.4525 (DYS391) to 0.9617 (DYS385). Rst and two multi-dimensional scaling plots showed that minor differences were observed when the Liaoning Han population was compared to the Jilin Han Chinese, Beijing Han Chinese, Liaoning Manchu, Liaoning Mongolian, Liaoning Xibe, Shandong Han Chinese, Jiangsu Han Chinese, Anhui Han Chinese, Guizhou Han Chinese and Liaoning Hui populations; by contrast, major differences were observed when the Shanxi Han Chinese, Yunnan Bai, Jiangxi Han Chinese, Guangdong Han Chinese, Liaoning Korean, Hunan Tujia, Guangxi Zhuang, Gansu Tibetan, Xishuangbanna Dai, South Korean, Japanese and Hunan Miao populations. For autosomal STR loci, DP ranged from 0.9621 (D2S1338) to 0.8177 (TPOX), with PE distributing from 0.7521 (D18S51) to 0.2988 (TH01). A population comparison was performed and no statistically significant differences were detected at any STR loci between Liaoning Han, China Dong, and Shaanxi Han populations. The results showed that the 25 Y-STR and 15 autosomal STR loci in the Liaoning Han population were valuable for forensic applications and human genetics, and Liaoning Han was an independent endogenous ethnicity with a unique subpopulation structure.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A cluster structure based on haplotypes of the Liaoning Han population in the YHRD database.
Fig 2
Fig 2. A MDS plot based on Rst between the Liaoning Han population and five reference populations (the Liaoning Han population is marked with yellow).
Fig 3
Fig 3. A MDS plot based on Rst between the Liaoning Han population and 22 East Asian populations (the Liaoning Han population is marked with yellow).
Fig 4
Fig 4. A phylogenetic tree showing the relationship between the Liaoning Han ethnic group and nine other populations.
The tree was constructed using allele frequency data from 15 autosomal STR loci for all populations (Shananxi Han; Jinan Han; Shanghai Han; China Dong; China Bouyei; China Miao; China Uygur; Japanese; Korean).
See this image and copyright information in PMC

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