Phytochemical, Antimicrobial, and Toxicological Evaluation of Traditional Herbs Used to Treat Sore Throat
- PMID: 27429983
- PMCID: PMC4939213
- DOI: 10.1155/2016/8503426
Phytochemical, Antimicrobial, and Toxicological Evaluation of Traditional Herbs Used to Treat Sore Throat
Abstract
The in vitro antibacterial activities of 29 traditional medicinal plants used in respiratory ailments were assessed on multidrug resistant Gram-positive and Gram-negative bacteria isolated from the sore throat patients and two reference strains. The methanolic, n-hexane, and aqueous extracts were screened by the agar well diffusion assay. Bioactive fractions of effective extracts were identified on TLC coupled with bioautography, while their toxicity was determined using haemolytic assay against human erythrocytes. Qualitative and quantitative phytochemical analysis of effective extracts was also performed. Methanolic extract of 18 plants showed antimicrobial activity against test strains. Adhatoda vasica (ZI = 17-21 mm, MIC: 7.12-62.5 μg/mL), Althaea officinalis (ZI = 16-20 mm, MIC: 15.62-31.25 μg/mL), Cordia latifolia (ZI = 16-20 mm, MIC: 12.62-62.5 μg/mL), Origanum vulgare (ZI = 20-22 mm, MIC: 3-15.62 μg/mL), Thymus vulgaris (ZI = 21-25 mm, MIC: 7.81-31.25 μg/mL), and Ziziphus jujuba (ZI = 14-20 mm, MIC: 7.81-31.25 μg/mL) showed significant antibacterial activity. Alkaloid fractions of Adhatoda vasica, Cordia latifolia, and Origanum vulgare and flavonoid fraction of the Althaea officinalis, Origanum vulgare, Thymus Vulgaris, and Ziziphus jujuba exhibited antimicrobial activity. Effective plant extracts show 0.93-0.7% erythrocyte haemolysis. The results obtained from this study provide a scientific rationale for the traditional use of these herbs and laid the basis for future studies to explore novel antimicrobial compounds.
Figures
Similar articles
-
Pharmacological, genotoxic and phytochemical properties of selected South African medicinal plants used in treating stomach-related ailments.J Ethnopharmacol. 2012 Feb 15;139(3):712-20. doi: 10.1016/j.jep.2011.11.034. Epub 2011 Dec 3. J Ethnopharmacol. 2012. PMID: 22154966
-
Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae).J Ethnopharmacol. 2013 Jul 9;148(2):486-91. doi: 10.1016/j.jep.2013.04.043. Epub 2013 May 14. J Ethnopharmacol. 2013. PMID: 23684720
-
In vitro-Scientific evaluation on antimicrobial, antioxidant, cytotoxic properties and phytochemical constituents of traditional coastal medicinal plants.Biomed Pharmacother. 2016 Oct;83:648-657. doi: 10.1016/j.biopha.2016.07.019. Epub 2016 Jul 25. Biomed Pharmacother. 2016. PMID: 27459122
-
Ethnobotany of the genus Taraxacum-Phytochemicals and antimicrobial activity.Phytother Res. 2018 Nov;32(11):2131-2145. doi: 10.1002/ptr.6157. Epub 2018 Jul 24. Phytother Res. 2018. PMID: 30039597 Review.
-
Marsh Mallow (Althaea officinalis L.) and Its Potency in the Treatment of Cough.Complement Med Res. 2020;27(3):174-183. doi: 10.1159/000503747. Epub 2019 Nov 26. Complement Med Res. 2020. PMID: 31770755 Review. English.
Cited by
-
Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspective.J Ethnopharmacol. 2022 Oct 28;297:115526. doi: 10.1016/j.jep.2022.115526. Epub 2022 Jul 14. J Ethnopharmacol. 2022. PMID: 35843408 Free PMC article. Review.
-
Antimicrobial screening of polyherbal formulations traditionally used against gastrointestinal diseases.Saudi J Biol Sci. 2021 Dec;28(12):6829-6843. doi: 10.1016/j.sjbs.2021.07.053. Epub 2021 Jul 24. Saudi J Biol Sci. 2021. PMID: 34866983 Free PMC article.
-
A Review of the Phytochemistry and Antimicrobial Properties of Origanum vulgare L. and Subspecies.Iran J Pharm Res. 2021 Spring;20(2):268-285. doi: 10.22037/ijpr.2020.113874.14539. Iran J Pharm Res. 2021. PMID: 34567161 Free PMC article. Review.
-
Use of traditional medicine for dental care by different ethnic groups in New Zealand.BMC Oral Health. 2020 Oct 12;20(1):280. doi: 10.1186/s12903-020-01272-7. BMC Oral Health. 2020. PMID: 33046025 Free PMC article.
-
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance.Antibiotics (Basel). 2020 Aug 4;9(8):480. doi: 10.3390/antibiotics9080480. Antibiotics (Basel). 2020. PMID: 32759771 Free PMC article. Review.
References
-
- Fry J. Common Diseases—Their Nature, Incidence and Care. 2nd. Lancaster, Pa, USA: MTP Press; 1979.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical