Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun 20;8(1):e2016031.
doi: 10.4084/MJHID.2016.031. eCollection 2016.

CMV in Hematopoietic Stem Cell Transplantation

Rafael de la Cámara  1
Affiliations
Review

CMV in Hematopoietic Stem Cell Transplantation

Rafael de la Cámara. Mediterr J Hematol Infect Dis. .

Abstract

Due to its negative impact on the outcome of stem cell transplant (SCT) and solid organ transplant patients (SOT) CMV has been called "the troll of transplantation". One of the greatest advances in the management of SCT has been the introduction of the preemptive strategy. Since its introduction, the incidence of the viremia, as expected, remains unchanged but there has been a marked decline in the incidence of early CMV disease. However, in spite of the advances in prevention of CMV disease, CMV is still today an important cause of morbidity and mortality. Late CMV disease is still occurring in a significant proportion of patients and the so-called indirect effects of CMV are causing significant morbidity and mortality. Fortunately there have been several advances in the development of new antivirals, adoptive immunotherapy and DNA-CMV vaccines that might transform the management of CMV in the near future.

PubMed Disclaimer

Figures

Figure 1
Figure 1
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rifkind D. Cytomegalovirus infection after renal transplantation. Arch Intern Med. 1965;116(4):554–8. doi: 10.1001/archinte.1965.03870040068014. - DOI - PubMed
    1. Petersen EA. Extrapulmonary cytomegalovirus disease in transplant patients. Transplant-Proc. 1991;23(2 Suppl 1):13–6. - PubMed
    1. Balfour HH., Jr Cytomegalovirus: the troll of transplantation. Arch Intern Med. 1979;139(3):279–80. doi: 10.1001/archinte.1979.03630400011006. - DOI - PubMed
    1. Marty FM, Ljungman P, Papanicolaou GA, Winston DJ, Chemaly RF, Strasfeld L, et al. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial. The Lancet infectious diseases. 2011;11(4):284–92. doi: 10.1016/S1473-3099(11)70024-X. - DOI - PubMed
    1. Marty FM, Winston DJ, Rowley SD, Vance E, Papanicolaou GA, Mullane KM, et al. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med. 2013;369(13):1227–36. doi: 10.1056/NEJMoa1303688. - DOI - PubMed