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. 2016:2016:4025167.
doi: 10.1155/2016/4025167. Epub 2016 Jun 15.

Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement

Mingyuan Huang  1 , Wenjing Du  2 , Jun Liu  3 , Haiyang Zhang  4 , Longbin Cao  3 , Weiqing Yang  3 , Hui Zhang  5 , Zhiyong Wang  3 , Pei Wei  3 , Weiquan Wu  3 , Zhulin Huang  1 , Ying Fang  1 , Qiling Lin  1 , Xingwen Qin  1 , Zhizhong Zhang  4 , Keyuan Zhou  3 , Jincheng Zeng  3
Affiliations

Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement

Mingyuan Huang et al. Mediators Inflamm. 2016.

Abstract

Enterovirus 71 (EV71) is a major pathogen for severe hand, foot, and mouth disease (HFMD), which leads to severe neurological complications and has high morbidity and mortality. Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality. Here, we found that serum IL-27 levels were significantly higher in stage III EV71-infected HFMD patients with early cardiopulmonary failure and strong correlation with CRP levels. IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage. IL-27 can be used as an prediction indicator for early cardiopulmonary failure in EV71-infected children with CNS involvement.

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Figures

Figure 1
Figure 1
Serum IL-27 levels in EV71-infected patients. Serum IL-27 levels in 127 EV71-infected HFMD patients (including 55 clinical stage II cases, 42 stage III cases, and 30 stage IV cases) and 95 healthy controls were detected by ELISA. Values are expressed as means ± SEM. (a) Serum IL-27 levels were significantly higher in EV71-infected HFMD patients than in healthy controls (P < 0.01). (b) Serum IL-27 levels in clinical stage III EV71-infected HFMD patients were higher than clinical stage II and clinical stage IV EV71-infected patients (P < 0.05). (c) Serum IL-27 levels in followed-up stage IV patients, the day of admission (TP0), the day the disease improved (TP1), and the day the disease recovered (TP2). ∗ P < 0.05; ∗∗ P < 0.01; ∗∗∗ P < 0.001.
Figure 2
Figure 2
Correlation of serum IL-27 levels with CRP levels. (a) CRP levels in stage II, III, and IV EV71-infected patients. (b) Correlations of serum IL-27 levels with CRP levels in stage II EV71-infected patients. (c) Correlations of serum IL-27 levels with CRP levels in stage III EV71-infected patients. (d) Correlations of serum IL-27 levels with CRP levels in stage IV EV71-infected patients. ∗ P < 0.05; ∗∗∗ P < 0.001.
Figure 3
Figure 3
Relationship between serum IL-27 levels and IL27p28 polymorphism in EV71-infected patients. Serum IL-27 levels were measured in 127 individuals for each IL27p28 polymorphism (rs181206, rs153109, and rs17855750) in EV71-infected patients. Values are expressed as means ± SEM. No associations were found between rs181206 (a), rs153109 (b), and rs17855750 (c) and serum IL-27 levels in EV71-infected patients.
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