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Review
. 2016 Nov;10(6):462-478.
doi: 10.1111/irv.12406. Epub 2016 Aug 8.

A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu

Louise E Smith  1 , Donatella D'Antoni  2 , Vageesh Jain  1 , Julia M Pearce  3 , John Weinman  2 , G James Rubin  4
Affiliations
Review

A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu

Louise E Smith et al. Influenza Other Respir Viruses. 2016 Nov.

Abstract

The aim of this review was to identify factors predicting actual or intended adherence to antivirals as treatment or prophylaxis for influenza. Literature from inception to March 2015 was systematically reviewed to find studies reporting predictors of adherence to antivirals and self-reported reasons for non-adherence to antivirals. Twenty-six studies were included in the review; twenty identified through the literature search and six through other means. Of these studies, 18 assessed predictors of actual adherence to antivirals, whereas eight assessed predictors of intended adherence. The most commonly found predictor of, and self-reported reason for, non-adherence was the occurrence of side effects. Other predictors include perceptions surrounding self-efficacy, response efficacy and perceived personal consequences as well as social influences of others' experiences of taking antivirals. Predictors identified in this review can be used to help inform communications to increase adherence to antivirals in both seasonal and pandemic influenza.

Keywords: adherence; antivirals; influenza; pandemic.

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References

    1. Burch J, Corbett M, Stock C, et al. Prescription of anti‐influenza drugs for healthy adults: a systematic review and meta‐analysis. Lancet Infect Dis. 2009;9:537–45. - PubMed
    1. Tamiflu . Flu treatment for adults | tamiflu® (oseltamivir phosphate) 2014. http://www.tamiflu.com/tamiflu-for-adults;jsessionid=uZNk-Cz2HqNTigzkzew.... Accessed January 23, 2014.
    1. National Audit Office . Access to Clinical Trial Information and the Stockpiling of Tamiflu. In: Department of Health, ed. London: The Stationery Office; 2013.
    1. Singer AC, Jarhult JD, Grabic R, et al. Compliance to oseltamivir among two populations in Oxfordshire, United Kingdom affected by influenza A(H1N1)pdm09, November 2009–a waste water epidemiology study. PLoS ONE. 2013;8:e60221. - PMC - PubMed
    1. Sadique MZ, Adams EJ, Edmunds WJ. Estimating the costs of school closure for mitigating an influenza pandemic. BMC Public Health. 2008;8:135. - PMC - PubMed

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