T-Cell Abnormalities in Common Variable Immunodeficiency

doi:10.18176/jiaci.0069

Review

. 2016;26(4):233-43.

doi: 10.18176/jiaci.0069. Epub 2016 Apr 15.

T-Cell Abnormalities in Common Variable Immunodeficiency

G Azizi^{1

2

3}, N Rezaei^{2

4

5}, F Kiaee^{2

3}, N Tavakolinia^{2

3}, R Yazdani⁶, A Mirshafiey⁷, A Aghamohammadi^{2

3}

Affiliations

¹ Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
² Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁴ Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁶ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁷ Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27374799
DOI: 10.18176/jiaci.0069

Free article

Review

T-Cell Abnormalities in Common Variable Immunodeficiency

G Azizi et al. J Investig Allergol Clin Immunol. 2016.

Free article

. 2016;26(4):233-43.

doi: 10.18176/jiaci.0069. Epub 2016 Apr 15.

Authors

G Azizi^{1

2

3}, N Rezaei^{2

4

5}, F Kiaee^{2

3}, N Tavakolinia^{2

3}, R Yazdani⁶, A Mirshafiey⁷, A Aghamohammadi^{2

3}

Affiliations

¹ Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
² Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁴ Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁶ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁷ Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27374799
DOI: 10.18176/jiaci.0069

Abstract

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients.

Keywords: Common variable immunodeficiency; Helper T cells; Regulatory T cells; T cell.

PubMed Disclaimer

Cited by

Immunological biomarkers associated with survival in a cohort of Argentinian patients with common variable immunodeficiency.
Kahn A, Luque G, Cuestas E, Basquiera A, Ricchi B, Schmitz-Abe K, Charbonnier LM, Benamar M, Motrich RD, Chatila TA, Rivero VE. Kahn A, et al. J Allergy Clin Immunol Glob. 2024 Jul 23;3(4):100311. doi: 10.1016/j.jacig.2024.100311. eCollection 2024 Nov. J Allergy Clin Immunol Glob. 2024. PMID: 39282620 Free PMC article.
B Cell Response Induced by SARS-CoV-2 Infection Is Boosted by the BNT162b2 Vaccine in Primary Antibody Deficiencies.
Pulvirenti F, Fernandez Salinas A, Milito C, Terreri S, Piano Mortari E, Quintarelli C, Di Cecca S, Lagnese G, Punziano A, Guercio M, Bonanni L, Auria S, Villani F, Albano C, Locatelli F, Spadaro G, Carsetti R, Quinti I. Pulvirenti F, et al. Cells. 2021 Oct 27;10(11):2915. doi: 10.3390/cells10112915. Cells. 2021. PMID: 34831138 Free PMC article.
Patients with Common Variable Immunodeficiency Complicated by Autoimmune Phenomena Have Lymphopenia and Reduced Treg, Th17, and NK Cells.
Więsik-Szewczyk E, Rutkowska E, Kwiecień I, Korzeniowska M, Sołdacki D, Jahnz-Różyk K. Więsik-Szewczyk E, et al. J Clin Med. 2021 Jul 29;10(15):3356. doi: 10.3390/jcm10153356. J Clin Med. 2021. PMID: 34362140 Free PMC article.
Equine common variable immunodeficiency: lessons from 100 clinical cases.
Julia M, Felippe B. Julia M, et al. Equine Vet Educ. 2024 Oct;36(10):543-554. doi: 10.1111/eve.13948. Epub 2024 Jan 31. Equine Vet Educ. 2024. PMID: 39555145
Chronic Diarrhea with Villous Blunting of the Small Intestine Under Capsule Endoscopy in Common Variable Immunodeficiency and X-Linked Agammaglobulinemia: A Case Series.
Deng F, Wang H, Wang X. Deng F, et al. J Asthma Allergy. 2023 Sep 22;16:997-1006. doi: 10.2147/JAA.S418996. eCollection 2023. J Asthma Allergy. 2023. PMID: 37772267 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Esmon Publicidad
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

T-Cell Abnormalities in Common Variable Immunodeficiency

Affiliations

T-Cell Abnormalities in Common Variable Immunodeficiency

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources