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. 2016 Jul-Sep;29(3):318-24.
doi: 10.20524/aog.2016.0025. Epub 2016 Mar 17.

Importance of colonoscopy in patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma

Kei Tominaga  1 , Hisashi Doyama  1 , Hiroyoshi Nakanishi  1 , Naohiro Yoshida  1 , Yasuhito Takeda  1 , Ryosuke Ota  1 , Kunihiro Tsuji  1 , Kazuhiro Matsunaga  1 , Shigetsugu Tsuji  1 , Kenichi Takemura  1 , Shinya Yamada  1 , Kazuyoshi Katayanagi  2 , Hiroshi Kurumaya  2
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Importance of colonoscopy in patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma

Kei Tominaga et al. Ann Gastroenterol. 2016 Jul-Sep.

Abstract

Background: The aim of the study was to clarify the frequency of colorectal neoplasm (CRN) complicating superficial esophageal squamous cell carcinoma (ESCC) and the need for colonoscopy.

Methods: We retrospectively reviewed 101 patients who had undergone initial endoscopic resection (ER) for superficial ESCC. Control group participants were age- and sex-matched asymptomatic subjects screened at our hospital over the same period of time. Advanced adenoma was defined as an adenoma ≥10 mm, with villous features, or high-grade dysplasia. Advanced CRN referred to advanced adenoma or cancer. We measured the incidence of advanced CRN in superficial ESCC and controls, and we compared the characteristics of superficial ESCC patients with and without advanced CRN.

Results: In the superficial ESCC group, advanced CRNs were found in 17 patients (16.8%). A history of smoking alone was found to be a significant risk factor of advanced CRN [odds ratio 6.02 (95% CI 1.30-27.8), P=0.005].

Conclusion: The frequency of synchronous advanced CRN is high in superficial ESCC patients subjected to ER. Colonoscopy should be highly considered for most patients who undergo ER for superficial ESCC with a history of smoking, and is recommended even in superficial ESCC patients.

Keywords: Advanced adenoma; colonoscopy; colorectal neoplasm; esophageal squamous cell carcinoma.

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Conflict of interest statement

Conflict of Interest: None

Figures

Figure 1
Figure 1
Flowchart of the review and analysis ESCC, esophageal squamous cell carcinoma; ER, endoscopic resection
See this image and copyright information in PMC

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