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. 1989 May;59(5):750-4.
doi: 10.1038/bjc.1989.157.

Clonal allele loss in gastrointestinal cancers

M F Fey  1 , C Hesketh, J S Wainscoat, S Gendler, S L Thein
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Free PMC article

Clonal allele loss in gastrointestinal cancers

M F Fey et al. Br J Cancer. 1989 May.
Free PMC article

Abstract

Using a panel of DNA probes for hypervariable DNA regions we screened 52 gastrointestinal carcinomas for clonal allele losses on chromosomes 1, 5, 7, 12, 16 and 17. A total of 24/35 informative cases of colorectal cancers showed loss of constitutional heterozygosity at a locus on chromosome 17p, while 9/31 cases informative for a locus on 5q showed allele loss. Loss of sequences at 5q was linked to allele loss at 17p with a single exception. In gastric cancers loss of heterozygosity most frequently occurred at 1q (5/10 tumours) and at 12q (6/11 tumours). Gastrointestinal tumours show consistent chromosomal losses and the loci involved are different in gastric and colorectal cancers.

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References

    1. Science. 1983 Jul 15;221(4607):227-36 - PubMed
    1. Genomics. 1988 Feb;2(2):180-4 - PubMed
    1. N Engl J Med. 1984 Sep 27;311(13):812-8 - PubMed
    1. Science. 1985 Apr 26;228(4698):501-3 - PubMed
    1. Science. 1986 Jan 17;231(4735):261-5 - PubMed

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