Urothelial carcinoma management in elderly or unfit patients

doi:10.1016/j.ejcsup.2016.01.001

. 2016 Mar;14(1):1-20.

doi: 10.1016/j.ejcsup.2016.01.001. Epub 2016 Mar 22.

Urothelial carcinoma management in elderly or unfit patients

Joaquim Bellmunt¹, Nicolas Mottet², Maria De Santis³

Affiliations

¹ Bladder Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
² Department of Urology, CHU de Saint-Etienne, University Jean Monnet, St Etienne, France.
³ University of Warwick, Cancer Research Unit, Coventry, UK.

PMID: 27358584
PMCID: PMC4917740
DOI: 10.1016/j.ejcsup.2016.01.001

Urothelial carcinoma management in elderly or unfit patients

Joaquim Bellmunt et al. EJC Suppl. 2016 Mar.

. 2016 Mar;14(1):1-20.

doi: 10.1016/j.ejcsup.2016.01.001. Epub 2016 Mar 22.

Authors

Joaquim Bellmunt¹, Nicolas Mottet², Maria De Santis³

Affiliations

¹ Bladder Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
² Department of Urology, CHU de Saint-Etienne, University Jean Monnet, St Etienne, France.
³ University of Warwick, Cancer Research Unit, Coventry, UK.

PMID: 27358584
PMCID: PMC4917740
DOI: 10.1016/j.ejcsup.2016.01.001

No abstract available

Keywords: Chemotherapy; Cisplatin; Cisplatin ‘unfit’ patients; Upper tract urothelial carcinoma; Urothelial carcinoma; Vinflunine.

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Figures

**Fig. 1**
The G-8 geriatric screening tool (based on [19]). ADL, activities of daily living; CISR-G, cumulative illness rating scale for geriatrics; IADL, instrumental activities of daily living.

**Fig. 2**
Distribution of primary therapies received by MIBC patients by age group . Reproduced with permission. © European Association of Urology 2012.

**Fig. 3**
Proposed flowchart for the management of UTUC .*In patients with solitary kidney, consider a more conservative approach. CT, computed tomography; RNU, radical nephroureterectomy; UTUC, upper urinary tract urothelial cell carcinoma.

See this image and copyright information in PMC

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References

1. Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. Available from: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx (accessed April 2015).
1. United Nations Department of Economic and Social Affairs Population Division. World population ageing: 1950–2050. Available from: http://www.un.org/esa/population/publications/worldageing19502050/ (accessed April 2015).
1. Gore J.L., Litwin M.S., Lai J. Use of radical cystectomy for patients with invasive bladder cancer. J Natl Cancer Inst. 2010;102:802–811. - PMC - PubMed
1. Gray P.J., Fedewa S.A., Shipley W.U. Use of potentially curative therapies for muscle-invasive bladder cancer in the United States: results from the National Cancer Data Base. Eur Urol. 2013;63:823–829. - PubMed
1. Balar A., Bajorin D.F., Milowsky M.I. Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy. Ther Adv Urol. 2011;3:107–117. - PMC - PubMed

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[1] Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. Available from: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx (accessed April 2015).

[2] Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. Available from: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx (accessed April 2015).

[3] United Nations Department of Economic and Social Affairs Population Division. World population ageing: 1950–2050. Available from: http://www.un.org/esa/population/publications/worldageing19502050/ (accessed April 2015).

[4] United Nations Department of Economic and Social Affairs Population Division. World population ageing: 1950–2050. Available from: http://www.un.org/esa/population/publications/worldageing19502050/ (accessed April 2015).

[5] Gore J.L., Litwin M.S., Lai J. Use of radical cystectomy for patients with invasive bladder cancer. J Natl Cancer Inst. 2010;102:802–811. - PMC - PubMed

[6] Gore J.L., Litwin M.S., Lai J. Use of radical cystectomy for patients with invasive bladder cancer. J Natl Cancer Inst. 2010;102:802–811. - PMC - PubMed

[7] Gray P.J., Fedewa S.A., Shipley W.U. Use of potentially curative therapies for muscle-invasive bladder cancer in the United States: results from the National Cancer Data Base. Eur Urol. 2013;63:823–829. - PubMed

[8] Gray P.J., Fedewa S.A., Shipley W.U. Use of potentially curative therapies for muscle-invasive bladder cancer in the United States: results from the National Cancer Data Base. Eur Urol. 2013;63:823–829. - PubMed

[9] Balar A., Bajorin D.F., Milowsky M.I. Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy. Ther Adv Urol. 2011;3:107–117. - PMC - PubMed

[10] Balar A., Bajorin D.F., Milowsky M.I. Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy. Ther Adv Urol. 2011;3:107–117. - PMC - PubMed

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Urothelial carcinoma management in elderly or unfit patients

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Urothelial carcinoma management in elderly or unfit patients

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