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Review
. 2016 Jun 25;68(3):335-42.

[Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus]

[Article in Chinese]
Yun-Li Zhang  1   2 , Lin Wang  3
Affiliations
  • PMID: 27350206
Free article
Review

[Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus]

[Article in Chinese]
Yun-Li Zhang et al. Sheng Li Xue Bao. .
Free article

Abstract

The hippocampus not only plays a role in appetite and energy balance, but also is particularly important in learning and memory. Figuring out the relationships of hippocampal glucose transporter 4 (GLUT4) with hippocampal glucose metabolism and hippocampus-dependent cognitive function is very important to clearly understand the pathophysiological basis of nutritional obesity and diabetes-related diseases, and treat obesity and cognitive dysfunction. Therefore, this study reviewed recent researches conducted on hippocampal GLUT4, hippocampal glucose metabolism, and hippocampus-dependent cognitive function. In this review, we mainly discussed: (1) The structure of GLUT4 and the distribution and function of GLUT4 in the hippocampus; (2) The translocation of GLUT4 in the hippocampus; (3) The relationships of the PI3K-Akt-GLUT4 signaling pathway with the high fat diet-induced changes of cognitive function and the glucose metabolism in the hippocampus; (4) The associations of the PI3K-Akt-GLUT4 signaling pathway with the diabetes-related cognitive dysfunction in the hippocampus; (5) The potential mechanisms of cognitive dysfunction induced by glucose metabolic disorder.

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