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. 2016 Aug;48(2):215-9.
doi: 10.1016/j.ijantimicag.2016.05.003. Epub 2016 Jun 8.

Virological response to peramivir treatment in adults hospitalised for influenza-associated lower respiratory tract infections

N Lee  1 , P K S Chan  2 , W W S Tam  3 , M C W Chan  4 , G C Y Lui  5 , A K Kwok  4 , F W S Ko  5 , S S S Ng  5 , I M H Yung  5 , R Y K Wong  5 , D S C Hui  6
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Virological response to peramivir treatment in adults hospitalised for influenza-associated lower respiratory tract infections

N Lee et al. Int J Antimicrob Agents. 2016 Aug.

Abstract

An open-label trial on intravenous peramivir was conducted among adult patients hospitalised for influenza-associated lower respiratory tract complications (LRTCs). Virus culture and quantitative reverse transcription PCR (qRT-PCR) were performed serially until Day 10. Peramivir treatment was associated with viral RNA decline as well as culture and RNA negativity, which occurred at rates comparable with those of oseltamivir: by Day 5, viral load decline -2.5 log10 copies/mL [βinteraction -0.071, standard error (SE) 0.121, 95% confidence interval (CI) -0.309 to 0.167]; culture-negative, 94% (vs. 95%); and RNA-negative, 44% (vs. 36%). Extended treatment of >5 days was required in 69% of cases because of slow clinical resolution and viral clearance in LRTCs. Peramivir was well tolerated. These data are useful for future trial design in this unique population.

Keywords: Influenza; Lower respiratory tract complications; Peramivir.

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