doi: 10.1016/0006-291x(89)91574-x.
Rabbit brown adipose tissue uncoupling protein MRNA: use of only one of two polyadenylation signals in its processing
Affiliations
- PMID: 2730654
- DOI: 10.1016/0006-291x(89)91574-x
Item in Clipboard
Rabbit brown adipose tissue uncoupling protein MRNA: use of only one of two polyadenylation signals in its processing
Biochem Biophys Res Commun.
.
Abstract
A cDNA containing the complete coding sequence of rabbit brown adipose tissue uncoupling protein was isolated and sequenced. The coding region is 80.6% identical to rat UCP cDNA and the protein is about 86% identical to the rat and hamster proteins. Despite the presence of 2 AATAAA polyadenylation consensus sequences in rabbit UCP cDNA, only one rabbit UCP mRNA was detected indicating that only the 3'-downstream signal is used in contrast to rat and mouse where both are used.
Similar articles
-
Uncoupling protein and its mRNA in brown adipose tissue of newborn rabbits.Can J Physiol Pharmacol. 1989 Jan;67(1):54-8. doi: 10.1139/y89-009. Can J Physiol Pharmacol. 1989. PMID: 2713755
-
The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue.Int J Biochem. 1991;23(9):791-801. doi: 10.1016/0020-711x(91)90062-r. Int J Biochem. 1991. PMID: 1773883 Review. No abstract available.
-
Topogenesis of mitochondrial inner membrane uncoupling protein. Rerouting transmembrane segments to the soluble matrix compartment.J Cell Biol. 1988 Aug;107(2):503-9. doi: 10.1083/jcb.107.2.503. J Cell Biol. 1988. PMID: 3417758 Free PMC article.
-
Oligonucleotide probe for the cross-species measurement of the mRNA for uncoupling protein in brown adipose tissue.Biochem Soc Trans. 1990 Dec;18(6):1261. doi: 10.1042/bst0181261. Biochem Soc Trans. 1990. PMID: 2088904 No abstract available.
-
Structure and function of the uncoupling protein from brown adipose tissue.Biochim Biophys Acta. 1999 Jan 8;1415(2):271-96. doi: 10.1016/s0005-2736(98)00232-6. Biochim Biophys Acta. 1999. PMID: 9889383 Review. No abstract available.
Cited by
-
Chemical, immunological, enzymatic, and genetic approaches to studying the arrangement of the peptide chain of the ADP/ATP carrier in the mitochondrial membrane.J Bioenerg Biomembr. 1993 Oct;25(5):459-72. doi: 10.1007/BF01108403. J Bioenerg Biomembr. 1993. PMID: 8132486 Review.
-
CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.EMBO J. 2018 Oct 15;37(20):e99071. doi: 10.15252/embj.201899071. Epub 2018 Sep 3. EMBO J. 2018. PMID: 30177570 Free PMC article.
-
Alternative Polyadenylation and Differential Regulation of Ucp1: Implications for Brown Adipose Tissue Thermogenesis Across Species.Front Pediatr. 2021 Feb 9;8:612279. doi: 10.3389/fped.2020.612279. eCollection 2020. Front Pediatr. 2021. PMID: 33634052 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
