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Review
. 2016 Sep:111:133-151.
doi: 10.1016/j.phrs.2016.06.008. Epub 2016 Jun 9.

Palmitoylation in Alzheimer's disease and other neurodegenerative diseases

Eunsil Cho  1 , Mikyoung Park  2
Affiliations
Free article
Review

Palmitoylation in Alzheimer's disease and other neurodegenerative diseases

Eunsil Cho et al. Pharmacol Res. 2016 Sep.
Free article

Abstract

Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulating palmitoylation are the enzymes that mediate palmitoylation and depalmitoylation which are palmitoyl acyltransferases (PATs) and protein thioesterases, respectively. In this review, we will provide and discuss current understandings on palmitoyation/depalmitoylation control mediated by PATs and/or protein thioesterases for neuronal functions in general and also for Alzheimer's disease in particular, and other neurodegenerative diseases such as Huntington's disease, schizophrenia and intellectual disability.

Keywords: Alzheimer’s disease; neurodegenerative diseases; palmitoyl acyltransferases; palmitoylation; posttranslational modifications; protein thioesterases.

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