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Review
. 2016 Jun 3;17(6):864.
doi: 10.3390/ijms17060864.

The MicroRNA-21 in Autoimmune Diseases

Shaowen Wang  1 , Xiaochun Wan  2 , Qingguo Ruan  3
Affiliations
Review

The MicroRNA-21 in Autoimmune Diseases

Shaowen Wang et al. Int J Mol Sci. .

Abstract

MicroRNA-21 (miR-21) is an oncomiR and significantly upregulated in a wide range of cancers. It is strongly involved in apoptosis and oncogenesis, since most of its reported targets are tumor suppressors. Recently, miR-21 was found to be correlated with the pathogenesis of autoimmune diseases and may play an essential role in regulating autoimmune responses. In particular, miR-21 promotes Th17 cell differentiation, which mediates the development of multiple autoimmune diseases. In this article, we review the current research on the mechanisms that regulate miR-21 expression, the potential of miR-21 as a diagnostic biomarker for autoimmune disease and the mechanisms by which miR-21 promotes the development of autoimmune disease. We also discussed the therapeutic potential of targeting miR-21 in treating patients with autoimmune disease.

Keywords: Th17; apoptosis; autoimmune disease; miR-21.

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