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. 2016 Dec;10(4):315-330.
doi: 10.1007/s12079-016-0331-0. Epub 2016 Jun 7.

Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren's disease

Massimiliano Tripoli  1 , Adriana Cordova  2 , Francesco Moschella  2
Affiliations

Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren's disease

Massimiliano Tripoli et al. J Cell Commun Signal. 2016 Dec.

Abstract

The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet fully understood. It would appear certain that the "abnormal" fibroblasts continuously synthesise profibrotic cytokines which are able to determine the activation to myofibroblasts, to stimulate them to the further proliferation and synthesis of other cytokines, to modify the cells' differentiation and ultrastructural characteristics, as well as the production of matrix and other proteins. Several fibroblast growth factors have been suggested to be responsible of an abnormal cell activation with an aberrantly elevated collagen synthesis and extracellular deposition in Dupuytren's disease, as TGF-Beta, TNF-Alfa, PDGF, GM-CSF, free radicals, metalloproteinases, sex hormones, gene modified expression, mechanical stimulation. The Authors review the current state of knowledge in the field, by analyzing the role of these cytokines in the palmar fibromatosis.

Keywords: Cytokines; Dupuytren’s disease; Fibroblast.

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Conflict of interest statement

Compliance with ethical standards Funding None. Conflicts of interest None declared. Ethical approval Not required. Financial disclosure The authors disclose any financial and personal relationships with other people or organisations that could inappropriately influence (bias) their work.

Figures

Fig. 1
Fig. 1
The fibroblast is the type of cell most representative of connective tissue and the superficial palmar fascia. The figure shows a section of the superficial palmar fascia showing the immunohistochemical H&E-stained fibroblasts, 50 x
Fig. 2
Fig. 2
Hystological and immunohistochemical studies on cytoskeleton performed using monoclonal antibodies made it possible to classify myofibroblasts into four morphological types. The figure shows “V” phenotype fibroblasts (azure) and vimentin-positive fibroblasts (brown) (immunohistochemical vimentin stain, 20x)
See this image and copyright information in PMC

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