Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

doi:10.1152/physiol.00047.2015

Review

. 2016 Jul;31(4):294-9.

doi: 10.1152/physiol.00047.2015.

Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

Valerie Sapp¹, Mohit Jain¹, Ronglih Liao²

Affiliations

¹ Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
² Division of Genetics and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

PMID: 27252164
PMCID: PMC6195664
DOI: 10.1152/physiol.00047.2015

Review

Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

Valerie Sapp et al. Physiology (Bethesda). 2016 Jul.

. 2016 Jul;31(4):294-9.

doi: 10.1152/physiol.00047.2015.

Authors

Valerie Sapp¹, Mohit Jain¹, Ronglih Liao²

Affiliations

¹ Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
² Division of Genetics and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

PMID: 27252164
PMCID: PMC6195664
DOI: 10.1152/physiol.00047.2015

Abstract

Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the author(s).

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References

1. Bell D, Schluter KD, Zhou XJ, McDermott BJ, Piper HM. Hypertrophic effects of calcitonin gene-related peptide (CGRP) and amylin on adult mammalian ventricular cardiomyocytes. J Mol Cell Cardiol : 2433–2443, 1995. - PubMed
1. Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem Biophys Res Commun : 707–713, 2011. - PMC - PubMed
1. Braidy N, Gai WP, Xu YH, Sachdev P, Guillemin GJ, Jiang XM, Ballard JW, Horan MP, Fang ZM, Chong BH, Chan DK. Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts. Transl Neurodegener : 20, 2013. - PMC - PubMed
1. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res : 1008–1010, 2004. - PubMed
1. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res : 598–608, 2012. - PMC - PubMed

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[1] Bell D, Schluter KD, Zhou XJ, McDermott BJ, Piper HM. Hypertrophic effects of calcitonin gene-related peptide (CGRP) and amylin on adult mammalian ventricular cardiomyocytes. J Mol Cell Cardiol : 2433–2443, 1995. - PubMed

[2] Bell D, Schluter KD, Zhou XJ, McDermott BJ, Piper HM. Hypertrophic effects of calcitonin gene-related peptide (CGRP) and amylin on adult mammalian ventricular cardiomyocytes. J Mol Cell Cardiol : 2433–2443, 1995. - PubMed

[3] Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem Biophys Res Commun : 707–713, 2011. - PMC - PubMed

[4] Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem Biophys Res Commun : 707–713, 2011. - PMC - PubMed

[5] Braidy N, Gai WP, Xu YH, Sachdev P, Guillemin GJ, Jiang XM, Ballard JW, Horan MP, Fang ZM, Chong BH, Chan DK. Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts. Transl Neurodegener : 20, 2013. - PMC - PubMed

[6] Braidy N, Gai WP, Xu YH, Sachdev P, Guillemin GJ, Jiang XM, Ballard JW, Horan MP, Fang ZM, Chong BH, Chan DK. Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts. Transl Neurodegener : 20, 2013. - PMC - PubMed

[7] Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res : 1008–1010, 2004. - PubMed

[8] Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res : 1008–1010, 2004. - PubMed

[9] Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res : 598–608, 2012. - PMC - PubMed

[10] Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res : 598–608, 2012. - PMC - PubMed

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Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

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Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

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