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Review
. 2016:2016:2958210.
doi: 10.1155/2016/2958210. Epub 2016 Apr 28.

Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

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Review

Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

Piya Prajumwongs et al. Stem Cells Int. 2016.

Abstract

Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.

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Figures

Figure 1
Figure 1
Developmental links between the different stages of neural derivatives of hESCs and their in vivo counterparts. Neural derivatives exhibit several similar characteristics to in vivo counterparts. The corresponding in vivo developmental stages are indicated and matched with the in vitro populations.

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