Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

doi:10.1155/2016/2958210

Review

. 2016:2016:2958210.

doi: 10.1155/2016/2958210. Epub 2016 Apr 28.

Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

Piya Prajumwongs¹, Oratai Weeranantanapan², Thiranut Jaroonwitchawan¹, Parinya Noisa¹

Affiliations

¹ School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
² School of Anatomy, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

PMID: 27239201
PMCID: PMC4864561
DOI: 10.1155/2016/2958210

Review

Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

Piya Prajumwongs et al. Stem Cells Int. 2016.

. 2016:2016:2958210.

doi: 10.1155/2016/2958210. Epub 2016 Apr 28.

Authors

Piya Prajumwongs¹, Oratai Weeranantanapan², Thiranut Jaroonwitchawan¹, Parinya Noisa¹

Affiliations

¹ School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
² School of Anatomy, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

PMID: 27239201
PMCID: PMC4864561
DOI: 10.1155/2016/2958210

Abstract

Although the mechanism of neurogenesis has been well documented in other organisms, there might be fundamental differences between human and those species referring to species-specific context. Based on principles learned from other systems, it is found that the signaling pathways required for neural induction and specification of human embryonic stem cells (hESCs) recapitulated those in the early embryo development in vivo at certain degree. This underscores the usefulness of hESCs in understanding early human neural development and reinforces the need to integrate the principles of developmental biology and hESC biology for an efficient neural differentiation.

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Figures

**Figure 1**
Developmental links between the different stages of neural derivatives of hESCs and their in vivo counterparts. Neural derivatives exhibit several similar characteristics to in vivo counterparts. The corresponding in vivo developmental stages are indicated and matched with the in vitro populations.

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References

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1. Campbell K., Götz M. Radial glia: multi-purpose cells for vertebrate brain development. Trends in Neurosciences. 2002;25(5):235–238. doi: 10.1016/S0166-2236(02)02156-2. - DOI - PubMed
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1. Thomson J. A., Itskovitz-Eldor J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. - PubMed
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[1] Hamburger V. Ontogeny of neuroembryology. The Journal of Neuroscience. 1988;8(10):3535–3540. - PMC - PubMed

[2] Hamburger V. Ontogeny of neuroembryology. The Journal of Neuroscience. 1988;8(10):3535–3540. - PMC - PubMed

[3] Campbell K., Götz M. Radial glia: multi-purpose cells for vertebrate brain development. Trends in Neurosciences. 2002;25(5):235–238. doi: 10.1016/S0166-2236(02)02156-2. - DOI - PubMed

[4] Campbell K., Götz M. Radial glia: multi-purpose cells for vertebrate brain development. Trends in Neurosciences. 2002;25(5):235–238. doi: 10.1016/S0166-2236(02)02156-2. - DOI - PubMed

[5] Takahashi K., Tanabe K., Ohnuki M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–872. doi: 10.1016/j.cell.2007.11.019. - DOI - PubMed

[6] Takahashi K., Tanabe K., Ohnuki M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–872. doi: 10.1016/j.cell.2007.11.019. - DOI - PubMed

[7] Thomson J. A., Itskovitz-Eldor J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. - PubMed

[8] Thomson J. A., Itskovitz-Eldor J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. - PubMed

[9] Itskovitz-Eldor J., Schuldiner M., Karsenti D., et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Molecular Medicine. 2000;6(2):88–95. - PMC - PubMed

[10] Itskovitz-Eldor J., Schuldiner M., Karsenti D., et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Molecular Medicine. 2000;6(2):88–95. - PMC - PubMed

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Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

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Human Embryonic Stem Cells: A Model for the Study of Neural Development and Neurological Diseases

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