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Review
. 2016 Aug;90(2):153-9.
doi: 10.1124/mol.116.103713. Epub 2016 May 23.

Research Resources for Nuclear Receptor Signaling Pathways

Neil J McKenna  1
Affiliations
Review

Research Resources for Nuclear Receptor Signaling Pathways

Neil J McKenna. Mol Pharmacol. 2016 Aug.

Abstract

Nuclear receptor (NR) signaling pathways impact cellular function in a broad variety of tissues in both normal physiology and disease states. The complex tissue-specific biology of these pathways is an enduring impediment to the development of clinical NR small-molecule modulators that combine therapeutically desirable effects in specific target tissues with suppression of off-target effects in other tissues. Supporting the important primary research in this area is a variety of web-based resources that assist researchers in gaining an appreciation of the molecular determinants of the pharmacology of a NR pathway in a given tissue. In this study, selected representative examples of these tools are reviewed, along with discussions on how current and future generations of tools might optimally adapt to the future of NR signaling research.

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Figures

Fig. 1.
Fig. 1.
General schematic model of a NR signaling pathway. Abbreviations refer to the web resources listed in Table 1. AB, Allen Brain Atlas; BG, BIOGRID; BGS, BioGPS; CTD, Comparative Toxicogenomics Database; DAV, DAVID; DB, DrugBank; EG, Entrez Gene; EM, Edinburgh Mouse; ENC, ENCODE; ENR, ENRICHR; ENS, Ensembl; EX, Expression Atlas; GC, GeneCards; GSEA, GeneSet Enrichment Analysis; GtoP, International Union of Pharmacology Guide To Pharmacology; HM, Human Metabolite Database; HP, Human Protein Atlas; IPA, Ingenuity; KG, KEGG; NURSA, NURSA Transcriptomine; NB, NextBio; PC, Pathway Commons; PC. PharmGKB, Pharmacogenomics Knowledge Base PubChem; PP, Phosphosite Plus.
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