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Review
. 2016;49(6):e5183.
doi: 10.1590/1414-431X20165183. Epub 2016 May 10.

Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses

A S R Hudson  1 , A C Kunstetter  1 , W C Damasceno  1 , S P Wanner  1
Affiliations
Review

Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses

A S R Hudson et al. Braz J Med Biol Res. 2016.

Abstract

Physical exercise triggers coordinated physiological responses to meet the augmented metabolic demand of contracting muscles. To provide adequate responses, the brain must receive sensory information about the physiological status of peripheral tissues and organs, such as changes in osmolality, temperature and pH. Most of the receptors involved in these afferent pathways express ion channels, including transient receptor potential (TRP) channels, which are usually activated by more than one type of stimulus and are therefore considered polymodal receptors. Among these TRP channels, the TRPV1 channel (transient receptor potential vanilloid type 1 or capsaicin receptor) has well-documented functions in the modulation of pain sensation and thermoregulatory responses. However, the TRPV1 channel is also expressed in non-neural tissues, suggesting that this channel may perform a broad range of functions. In this review, we first present a brief overview of the available tools for studying the physiological roles of the TRPV1 channel. Then, we present the relationship between the TRPV1 channel and spontaneous locomotor activity, physical performance, and modulation of several physiological responses, including water and electrolyte balance, muscle hypertrophy, and metabolic, cardiovascular, gastrointestinal, and inflammatory responses. Altogether, the data presented herein indicate that the TPRV1 channel modulates many physiological functions other than nociception and thermoregulation. In addition, these data open new possibilities for investigating the role of this channel in the acute effects induced by a single bout of physical exercise and in the chronic effects induced by physical training.

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Figures

Figure 1
Figure 1. Transient receptor potential vanilloid type 1 (TRPV1) channel modulates spontaneous locomotor activity. The figure shows that aged Trpv1-knockout mice have a higher body mass and lower spontaneous locomotor activity than their genetically unaltered littermates. The figure was modified from Wanner et al. (32).
Figure 2
Figure 2. Systemic administration of a TRPV1 antagonist induces hyperthermia. The figure shows that subcutaneous injection of AMG517 (210 μg/kg, sc) increases the abdominal temperature of young mice maintained at 28°C. *Significant difference (P<0.05) compared to vehicle. TRPV1: transient receptor potential vanilloid type 1. The figure was modified from Wanner et al., 2012 (78).
Figure 3
Figure 3. Overview of the physiological functions exerted by transient receptor potential vanilloid type 1 (TRPV1) channels. The green boxes indicate responses that are mediated by TRPV1 channels during physical activity or exercise, whereas the red boxes indicate TRPV1-mediated physiological responses that have not been investigated under such conditions.
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