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Review
. 2016 May-Jun;22(3):173-82.
doi: 10.4103/1319-3767.182453.

Management of hepatitis c genotype 4 in the liver transplant setting

Waleed K Al-Hamoudi  1
Affiliations
Review

Management of hepatitis c genotype 4 in the liver transplant setting

Waleed K Al-Hamoudi. Saudi J Gastroenterol. 2016 May-Jun.

Abstract

End-stage liver disease secondary to hepatitis C virus (HCV) infection is the major indication for orthotopic liver transplantation (OLT) worldwide. The percentage of HCV patients infected with genotype 4 (G4) among recipients of OLT varies depending on geographic location. In the Middle East, including Saudi Arabia, G4 infection is the most common genotype among transplant recipients. Due to the low prevalence of HCV-G4 in Europe and the United States, this genotype has not been adequately studied in prospective trials evaluating treatment outcomes and remains the least studied variant. The aim of this review is to summarize the natural history and treatment outcome of HCV-G4 following liver transplantation, with particular attention to new HCV therapies. This review incorporates all published studies and abstracts including HCV-G4 patients.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Factors affecting the outcome of HCV-related transplantation
Figure 2
Figure 2
Natural history of recurrent HCV after liver transplantation and potential treatment strategies for HCV-G4 infection
See this image and copyright information in PMC

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