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Case Reports
. 2016 Aug;38(4):749-51.
doi: 10.1007/s11096-016-0316-3. Epub 2016 May 14.

Continuous intravenous infusion of enfuvirtide in a patient with a multidrug-resistant HIV strain

Robert W Neijzen  1 , Erik M Van Maarseveen  2 , Andy I M Hoepelman  3 , Annemarie M J Wensing  4 , Stefano Bonora  5 , Antonio D'Avolio  5 , Tania Mudrikova  3
Affiliations
Case Reports

Continuous intravenous infusion of enfuvirtide in a patient with a multidrug-resistant HIV strain

Robert W Neijzen et al. Int J Clin Pharm. 2016 Aug.

Abstract

Case description To evaluate whether continuous intravenous (i.v.) administration of enfuvirtide (T20) could be a suitable alternative to subcutaneous (s.c.) administration of T20 in a patient with extensively drug-resistant HIV experiencing difficulties administering T20 subcutaneously. T20 was administered to a patient through 100 mL cassettes once daily via a CADD. Plasma samples were drawn and the pharmacokinetic profile compared to that of s.c. twice daily administration of T20. Also, viral replication and CD4+ count were monitored over a period of 9 months for this study. Continuous i.v. administration of T20 resulted in significantly higher T20 plasma levels compared to s.c. administration, continued viral suppression, a rise in CD4+ count and strong patient preference over s.c. administration. Conclusion This method of T20 administration may be a suitable alternative for selected patients who are not able to tolerate it when given subcutaneously. It may even be considered a priori in selected patients with extensive viral resistance who are unable or unwilling to inject T20 subcutaneously.

Keywords: AIDS; Continuous intravenous therapy; Enfuvirtide; HIV; Resistance.

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References

    1. J Antimicrob Chemother. 2008 Aug;62(2):384-7 - PubMed
    1. Can J Vet Res. 1993 Oct;57(4):223-30 - PubMed
    1. J Theor Biol. 2008 Apr 7;251(3):541-51 - PubMed
    1. N Engl J Med. 2003 May 29;348(22):2175-85 - PubMed
    1. J Antimicrob Chemother. 2011 Sep;66(9):2099-106 - PubMed

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