Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

doi:10.1161/CIRCRESAHA.116.308699

Editorial

. 2016 May 13;118(10):1457-60.

doi: 10.1161/CIRCRESAHA.116.308699.

Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

Jun-Ichi Abe¹, Craig Morrell²

Affiliations

¹ From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.). jabe@mdanderson.org.
² From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).

PMID: 27174943
PMCID: PMC5137941
DOI: 10.1161/CIRCRESAHA.116.308699

Editorial

Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

Jun-Ichi Abe et al. Circ Res. 2016.

. 2016 May 13;118(10):1457-60.

doi: 10.1161/CIRCRESAHA.116.308699.

Authors

Jun-Ichi Abe¹, Craig Morrell²

Affiliations

¹ From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.). jabe@mdanderson.org.
² From the Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston (J.i.A); and Aab Cardiovascular Research Institute, University of Rochester, NY (C.M.).

PMID: 27174943
PMCID: PMC5137941
DOI: 10.1161/CIRCRESAHA.116.308699

No abstract available

Keywords: Editorials; Gsdm protein, mouse; caspase 1; inflammasomes necrosis pyroptosis.

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Figures

**Figure 1. Scheme for canonical and non-canonical inflammasome signalings**
(Adapted from Kayagaki et al with permission from Macmillan Publishers Ltd, copyright 2015)

See this image and copyright information in PMC

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References

1. Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F. Cleavage of gsdmd by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660–665. - PubMed
1. Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: The expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014;15:135–147. - PubMed
1. Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265:130–142. - PMC - PubMed
1. Zhao Y, Shao F. Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence. Curr Opin Microbiol. 2016;29:37–42. - PubMed
1. Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H. Caspase-1 inflammasome activation mediates homocysteine-induced pyrop-apoptosis in endothelial cells. Circulation Research. 2016;118 xxx-xxx [in this issue] - PMC - PubMed

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[1] Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F. Cleavage of gsdmd by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660–665. - PubMed

[2] Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F. Cleavage of gsdmd by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660–665. - PubMed

[3] Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: The expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014;15:135–147. - PubMed

[4] Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: The expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014;15:135–147. - PubMed

[5] Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265:130–142. - PMC - PubMed

[6] Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265:130–142. - PMC - PubMed

[7] Zhao Y, Shao F. Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence. Curr Opin Microbiol. 2016;29:37–42. - PubMed

[8] Zhao Y, Shao F. Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence. Curr Opin Microbiol. 2016;29:37–42. - PubMed

[9] Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H. Caspase-1 inflammasome activation mediates homocysteine-induced pyrop-apoptosis in endothelial cells. Circulation Research. 2016;118 xxx-xxx [in this issue] - PMC - PubMed

[10] Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H. Caspase-1 inflammasome activation mediates homocysteine-induced pyrop-apoptosis in endothelial cells. Circulation Research. 2016;118 xxx-xxx [in this issue] - PMC - PubMed

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Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

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Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

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