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Review
. 2016 May:38 Suppl 1:27-31.
doi: 10.1111/ijlh.12507. Epub 2016 May 9.

Laboratory testing for antiphospholipid syndrome

V Pengo  1 , A Banzato  1 , E Bison  1 , G Denas  1 , G Zoppellaro  1 , A Bracco  1 , S Padayattil Jose  1 , A Hoxha  2 , A Ruffatti  2
Affiliations
Review

Laboratory testing for antiphospholipid syndrome

V Pengo et al. Int J Lab Hematol. 2016 May.

Abstract

This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome (APS). After a general definition of APS, this study deals with appropriateness and timing in requesting the determination of antiphospholipid (aPL) antibodies. Lupus anticoagulant (LAC), anticardiolipin (aCL), and anti β2-glycoprotein I (aβGPI) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians. Finally, a personal definition of APS according to aPL antibody profile closes the manuscript.

Keywords: Phospholipid; laboratory; syndrome; testing.

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