Geroscience approaches to increase healthspan and slow aging

doi:10.12688/f1000research.7583.1

Review

. 2016 Apr 29:5:F1000 Faculty Rev-785.

doi: 10.12688/f1000research.7583.1. eCollection 2016.

Geroscience approaches to increase healthspan and slow aging

Simon Melov¹

Affiliations

PMID: 27158475
PMCID: PMC4856109
DOI: 10.12688/f1000research.7583.1

Review

Geroscience approaches to increase healthspan and slow aging

Simon Melov. F1000Res. 2016.

. 2016 Apr 29:5:F1000 Faculty Rev-785.

doi: 10.12688/f1000research.7583.1. eCollection 2016.

Author

Simon Melov¹

Affiliation

¹ Buck Institute for Research on Aging, Novato, CA, USA.

PMID: 27158475
PMCID: PMC4856109
DOI: 10.12688/f1000research.7583.1

Abstract

For decades, researchers in the biology of aging have focused on defining mechanisms that modulate aging by primarily studying a single metric, sometimes described as the "gold standard" lifespan. Increasingly, geroscience research is turning towards defining functional domains of aging such as the cardiovascular system, skeletal integrity, and metabolic health as being a more direct route to understand why tissues decline in function with age. Each model used in aging research has strengths and weaknesses, yet we know surprisingly little about how critical tissues decline in health with increasing age. Here I discuss popular model systems used in geroscience research and their utility as possible tools in preclinical studies in aging.

Keywords: Geroscience; healthspan; lifespan; longevity; slow aging.

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Conflict of interest statement

Competing interests: The author declares that he has no competing interests.

No competing interests were disclosed.

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References

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[1] Johnson TE: Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science. 1990;249(4971):908–12. 10.1126/science.2392681 - DOI - PubMed

[2] Johnson TE: Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science. 1990;249(4971):908–12. 10.1126/science.2392681 - DOI - PubMed

[3] Friedman DB, Johnson TE: Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol. 1988;43(4):B102–9. 10.1093/geronj/43.4.B102 - DOI - PubMed

[4] Friedman DB, Johnson TE: Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol. 1988;43(4):B102–9. 10.1093/geronj/43.4.B102 - DOI - PubMed

[5] Johnson TE, Wood WB: Genetic analysis of life-span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1982;79(21):6603–7. 10.1073/pnas.79.21.6603 - DOI - PMC - PubMed

[6] Johnson TE, Wood WB: Genetic analysis of life-span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1982;79(21):6603–7. 10.1073/pnas.79.21.6603 - DOI - PMC - PubMed

[7] Morris JZ, Tissenbaum HA, Ruvkun G: A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536–9. 10.1038/382536a0 - DOI - PubMed

[8] Morris JZ, Tissenbaum HA, Ruvkun G: A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536–9. 10.1038/382536a0 - DOI - PubMed

[9] Kenyon C, Chang J, Gensch E, et al. : A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):461–4. 10.1038/366461a0 - DOI - PubMed

[10] Kenyon C, Chang J, Gensch E, et al. : A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):461–4. 10.1038/366461a0 - DOI - PubMed

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Geroscience approaches to increase healthspan and slow aging

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Geroscience approaches to increase healthspan and slow aging

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