Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;33(6):399-409.
doi: 10.1007/s40266-016-0375-0.

Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia

Hiroyuki Umegaki  1
Affiliations
Review

Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia

Hiroyuki Umegaki. Drugs Aging. 2016 Jun.

Abstract

It has been established that diabetes mellitus (DM) is a risk factor for dementia, and recent studies have clearly shown that dementia is one of the complications of DM. The increase of cognitively impaired subjects with the progression of aging in the population is an urgent worldwide issue. Due to the pharmacological advancement in the field of DM, we now have many kinds of antidiabetic medications with a wide variety of mechanisms of action and characteristics. It is a good time to review the characteristics of each antidiabetic medication and the evidence related to their prevention of cognitive dysfunction or preservation of cognition. The available data on the effects of antidiabetics on cognitive dysfunction and dementia show that several of the antidiabetics have the potential to improve cognition. The accumulation of more data to determine the best ways to use antidiabetics in order to prevent cognitive impairment would be warranted. To this end, the present review will try to illustrate the horizon of achievement in this field.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. JAMA Neurol. 2015 Sep;72 (9):1013-20 - PubMed
    1. FASEB J. 2008 Jan;22(1):246-60 - PubMed
    1. Nat Rev Endocrinol. 2015 Dec;11(12):701-11 - PubMed
    1. J Neurochem. 2015 Oct;135(2):301-8 - PubMed
    1. J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1122-31 - PubMed

LinkOut - more resources