Perfect and Near-Perfect Adaptation in Cell Signaling
- PMID: 27135159
- DOI: 10.1016/j.cels.2016.02.006
Perfect and Near-Perfect Adaptation in Cell Signaling
Abstract
Adaptation is an important basic feature of cellular regulation. Previous theoretical work has identified three types of circuits-negative feedback loops, incoherent feedforward systems, and state-dependent inactivation systems-that can achieve perfect or near-perfect adaptation. Recent work has added another strategy, termed antithetic integral feedback, to the list of motifs capable of robust perfect adaptation. Here, we discuss the properties, limitations, and biological relevance of each of these circuits.
Copyright © 2016 Elsevier Inc. All rights reserved.
Similar articles
-
Guidelines for designing the antithetic feedback motif.Phys Biol. 2020 Aug 10;17(5):055002. doi: 10.1088/1478-3975/ab8454. Phys Biol. 2020. PMID: 32217822
-
Antithetic Integral Feedback Ensures Robust Perfect Adaptation in Noisy Biomolecular Networks.Cell Syst. 2016 Jan 27;2(1):15-26. doi: 10.1016/j.cels.2016.01.004. Epub 2016 Jan 27. Cell Syst. 2016. PMID: 27136686
-
Perfect adaptation in biology.Cell Syst. 2021 Jun 16;12(6):509-521. doi: 10.1016/j.cels.2021.05.020. Cell Syst. 2021. PMID: 34139163 Review.
-
A genetic mammalian proportional-integral feedback control circuit for robust and precise gene regulation.Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2122132119. doi: 10.1073/pnas.2122132119. Epub 2022 Jun 10. Proc Natl Acad Sci U S A. 2022. PMID: 35687671 Free PMC article.
-
Feedback loops shape cellular signals in space and time.Science. 2008 Oct 17;322(5900):390-5. doi: 10.1126/science.1160617. Science. 2008. PMID: 18927383 Free PMC article. Review.
Cited by
-
Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.J R Soc Interface. 2023 Jan;20(198):20220553. doi: 10.1098/rsif.2022.0553. Epub 2023 Jan 4. J R Soc Interface. 2023. PMID: 36596458 Free PMC article.
-
Stabilization of antithetic control via molecular buffering.J R Soc Interface. 2022 Mar;19(188):20210762. doi: 10.1098/rsif.2021.0762. Epub 2022 Mar 9. J R Soc Interface. 2022. PMID: 35259958 Free PMC article.
-
The topological requirements for robust perfect adaptation in networks of any size.Nat Commun. 2018 May 1;9(1):1757. doi: 10.1038/s41467-018-04151-6. Nat Commun. 2018. PMID: 29717141 Free PMC article.
-
Rapid prototyping and design of cybergenetic single-cell controllers.Nat Commun. 2021 Sep 24;12(1):5651. doi: 10.1038/s41467-021-25754-6. Nat Commun. 2021. PMID: 34561433 Free PMC article.
-
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells.J Exp Clin Cancer Res. 2024 Apr 9;43(1):107. doi: 10.1186/s13046-024-03031-w. J Exp Clin Cancer Res. 2024. PMID: 38594748 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources