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. 1989 Feb;27(2):205-13.
doi: 10.1111/j.1365-2125.1989.tb05352.x.

The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease

N R Scott  1 , D Stambuk, J Chakraborty, V Marks, M Y Morgan
Affiliations

The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease

N R Scott et al. Br J Clin Pharmacol. 1989 Feb.

Abstract

1. Serum and salivary concentrations of caffeine (1,3,7-trimethylxanthine) and its dimethylxanthine metabolites were measured in 10 healthy control subjects and in 19 patients with cirrhosis, for up to 96 h following a 400 mg oral caffeine load. 2. Serum and salivary caffeine concentrations correlated significantly (r = 0.954; P less than 0.001) and no significant differences were observed in the pharmacokinetic data derived from the respective concentration-time curves. 3. In the control subjects, basal salivary caffeine concentrations did not exceed 0.4 mg l-1. The median (range) basal salivary caffeine concentrations in patients with compensated cirrhosis (n = 10), 0.2 (0-0.7) mg l-1 and decompensated cirrhosis (n = 9), 0.7 (0-5.8) mg l-1, were not significantly different from control values, although three patients with decompensated cirrhosis had basal salivary caffeine values above 2.0 mg l-1. 4. In the patients with compensated cirrhosis, the median peak salivary caffeine concentration, 10.9 (8.2-16.5) mg l-1 was significantly greater than in controls, 7.1 (4.7-11.8) mg l-1 (P less than 0.01) and the median apparent volume of distribution was significantly reduced, 0.38 (0.19-0.49) vs 0.41 (0.23-0.63) l kg-1 (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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References

    1. Br J Surg. 1973 Aug;60(8):646-9 - PubMed
    1. Clin Pharmacol Ther. 1976 Oct;20(4):484-92 - PubMed
    1. Gastroenterology. 1977 Apr;72(4 Pt 1):573-83 - PubMed
    1. Clin Pharmacol Ther. 1978 Jul;24(1):40-5 - PubMed
    1. Dig Dis Sci. 1980 Mar;25(3):193-7 - PubMed