Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

doi:10.1016/j.it.2016.04.001

Review

. 2016 Jun;37(6):375-385.

doi: 10.1016/j.it.2016.04.001. Epub 2016 Apr 27.

Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

Grégoire Lauvau¹, Marie Boutet², Tere M Williams², Shu Shien Chin², Laurent Chorro²

Affiliations

¹ Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY, USA. Electronic address: gregoire.lauvau@einstein.yu.edu.
² Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY, USA.

PMID: 27131432
PMCID: PMC4885763
DOI: 10.1016/j.it.2016.04.001

Review

Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

Grégoire Lauvau et al. Trends Immunol. 2016 Jun.

. 2016 Jun;37(6):375-385.

doi: 10.1016/j.it.2016.04.001. Epub 2016 Apr 27.

Authors

Grégoire Lauvau¹, Marie Boutet², Tere M Williams², Shu Shien Chin², Laurent Chorro²

Affiliations

¹ Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY, USA. Electronic address: gregoire.lauvau@einstein.yu.edu.
² Albert Einstein College of Medicine, Department of Microbiology and Immunology, New York, NY, USA.

PMID: 27131432
PMCID: PMC4885763
DOI: 10.1016/j.it.2016.04.001

Abstract

Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the mechanisms by which these cells mediate effective protection in vivo. The picture that emerges presents memory CD8(+) T cells as early sensors of danger signals, mediating protective immunity both through licensing of cellular effectors of the innate immune system and via the canonical functions associated with memory T cells. We discuss implications for the development of T cell vaccines and therapies and highlight important areas in need of further investigation.

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Figures

**Figure 1. Illustration of memory CD8⁺ T cell-reactivation and protective immune response**
Schematic representation of the distinct phases and signals regulating pathogen-specific memory CD8⁺ T cell-reactivation and effective protection. Illustrated steps occur in secondary lymphoid organs, and for most part can be extended to mucosal tissues (See Review for specifics).

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References

1. Cui W, Kaech SM. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev. 2010;(236):151–66. - PMC - PubMed
1. Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity. 2014;41(6):886–97. - PMC - PubMed
1. Shin H, Iwasaki A. Tissue-resident memory T cells. Immunol Rev. 2013;255(1):165–81. - PMC - PubMed
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[1] Cui W, Kaech SM. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev. 2010;(236):151–66. - PMC - PubMed

[2] Cui W, Kaech SM. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev. 2010;(236):151–66. - PMC - PubMed

[3] Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity. 2014;41(6):886–97. - PMC - PubMed

[4] Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity. 2014;41(6):886–97. - PMC - PubMed

[5] Shin H, Iwasaki A. Tissue-resident memory T cells. Immunol Rev. 2013;255(1):165–81. - PMC - PubMed

[6] Shin H, Iwasaki A. Tissue-resident memory T cells. Immunol Rev. 2013;255(1):165–81. - PMC - PubMed

[7] Carbone FR. Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs. J Immunol. 2015;195(1):17–22. - PubMed

[8] Carbone FR. Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs. J Immunol. 2015;195(1):17–22. - PubMed

[9] Wherry EJ. T cell exhaustion. Nat Immunol. 2011;12(6):492–9. - PubMed

[10] Wherry EJ. T cell exhaustion. Nat Immunol. 2011;12(6):492–9. - PubMed

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Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

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Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection

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