The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis
- PMID: 27105081
- DOI: 10.1159/000445751
The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis
Abstract
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history.
Objective: This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender.
Methods: We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups.
Results: Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05).
Conclusion: PD incidence generally increases with age, although it may stabilize in those who are 80+.
© 2016 S. Karger AG, Basel.
Similar articles
-
The prevalence of Parkinson's disease: a systematic review and meta-analysis.Mov Disord. 2014 Nov;29(13):1583-90. doi: 10.1002/mds.25945. Epub 2014 Jun 28. Mov Disord. 2014. PMID: 24976103 Review.
-
Reproductive factors and risk of Parkinson's disease in women: A meta-analysis of observational studies.Behav Brain Res. 2017 Sep 29;335:103-110. doi: 10.1016/j.bbr.2017.07.025. Epub 2017 Jul 22. Behav Brain Res. 2017. PMID: 28743601 Review.
-
A systematic review of the worldwide prevalence and incidence of Parkinson's disease.J Med Assoc Thai. 2011 Jun;94(6):749-55. J Med Assoc Thai. 2011. PMID: 21696087 Review.
-
The prevalence and incidence of Parkinson's disease in China: a systematic review and meta-analysis.J Neural Transm (Vienna). 2014 Feb;121(2):123-34. doi: 10.1007/s00702-013-1092-z. Epub 2013 Sep 22. J Neural Transm (Vienna). 2014. PMID: 24057652 Review.
-
Incidence of Parkinson's disease in Bulgaria.Neuroepidemiology. 2010;34(2):76-82. doi: 10.1159/000264824. Epub 2009 Dec 11. Neuroepidemiology. 2010. PMID: 20016216
Cited by
-
Current Perspectives: Obesity and Neurodegeneration - Links and Risks.Degener Neurol Neuromuscul Dis. 2023 Dec 31;13:111-129. doi: 10.2147/DNND.S388579. eCollection 2023. Degener Neurol Neuromuscul Dis. 2023. PMID: 38196559 Free PMC article. Review.
-
GLP-1 receptor agonists for Parkinson's disease.Cochrane Database Syst Rev. 2020 Jul 23;7(7):CD012990. doi: 10.1002/14651858.CD012990.pub2. Cochrane Database Syst Rev. 2020. PMID: 32700772 Free PMC article.
-
Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets.Int J Mol Sci. 2023 Dec 1;24(23):17037. doi: 10.3390/ijms242317037. Int J Mol Sci. 2023. PMID: 38069360 Free PMC article. Review.
-
Treatment Patterns in Patients with Incident Parkinson's Disease in the United States.J Parkinsons Dis. 2019;9(4):749-759. doi: 10.3233/JPD-191636. J Parkinsons Dis. 2019. PMID: 31424419 Free PMC article.
-
A nationwide study of the incidence, prevalence and mortality of Parkinson's disease in the Norwegian population.NPJ Parkinsons Dis. 2022 Mar 2;8(1):19. doi: 10.1038/s41531-022-00280-4. NPJ Parkinsons Dis. 2022. PMID: 35236852 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
