Microtubules: 50 years on from the discovery of tubulin

doi:10.1038/nrm.2016.45

Review

. 2016 Apr 22;17(5):322-8.

doi: 10.1038/nrm.2016.45.

Microtubules: 50 years on from the discovery of tubulin

Gary Borisy¹, Rebecca Heald², Jonathon Howard³, Carsten Janke⁴, Andrea Musacchio⁵, Eva Nogales⁶

Affiliations

¹ Forsyth Institute, 245 First Street, Cambridge, Massachusetts 02142, USA.
² Division of Cell and Developmental Biology and Molecular and Cell Biology Department, University of California, Berkeley, California 94720, USA.
³ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.
⁴ Institut Curie, PSL Research University, CNRS UMR3348, Centre Universitaire, Bâtiment 110, F-91405 Orsay, France.
⁵ Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany; and the Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitätsstrasse, 45141 Essen, Germany.
⁶ Biochemistry, Biophysics and Structural Biology Division, Molecular and Cell Biology Department, University of California, Berkeley, California 94720-3220, USA; the Howard Hughes Medical Institute, Maryland, USA; and the Lawrence Berkeley National Laboratory, USA.

PMID: 27103327
PMCID: PMC5116387
DOI: 10.1038/nrm.2016.45

Review

Microtubules: 50 years on from the discovery of tubulin

Gary Borisy et al. Nat Rev Mol Cell Biol. 2016.

. 2016 Apr 22;17(5):322-8.

doi: 10.1038/nrm.2016.45.

Authors

Gary Borisy¹, Rebecca Heald², Jonathon Howard³, Carsten Janke⁴, Andrea Musacchio⁵, Eva Nogales⁶

Affiliations

¹ Forsyth Institute, 245 First Street, Cambridge, Massachusetts 02142, USA.
² Division of Cell and Developmental Biology and Molecular and Cell Biology Department, University of California, Berkeley, California 94720, USA.
³ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.
⁴ Institut Curie, PSL Research University, CNRS UMR3348, Centre Universitaire, Bâtiment 110, F-91405 Orsay, France.
⁵ Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany; and the Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitätsstrasse, 45141 Essen, Germany.
⁶ Biochemistry, Biophysics and Structural Biology Division, Molecular and Cell Biology Department, University of California, Berkeley, California 94720-3220, USA; the Howard Hughes Medical Institute, Maryland, USA; and the Lawrence Berkeley National Laboratory, USA.

PMID: 27103327
PMCID: PMC5116387
DOI: 10.1038/nrm.2016.45

Abstract

Next year will be the 50th anniversary of the discovery of tubulin. To celebrate this discovery, six leaders in the field of microtubule research reflect on key findings and technological breakthroughs over the past five decades, discuss implications for therapeutic applications and provide their thoughts on what questions need to be addressed in the near future.

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References

1. Borisy GG, Taylor EW. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J. Cell Biol. 1967;34:525–533. - PMC - PubMed
1. Borisy GG, Taylor EW. The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J. Cell Biol. 1967;34:535–548. - PMC - PubMed
1. Howard J, Hudspeth AJ, Vale RD. Movement of microtubules by single kinesin molecules. Nature. 1989;342:154–158. - PubMed
1. Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993;365:721–727. - PubMed
1. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984;312:237–242. - PubMed

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[1] Borisy GG, Taylor EW. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J. Cell Biol. 1967;34:525–533. - PMC - PubMed

[2] Borisy GG, Taylor EW. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J. Cell Biol. 1967;34:525–533. - PMC - PubMed

[3] Borisy GG, Taylor EW. The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J. Cell Biol. 1967;34:535–548. - PMC - PubMed

[4] Borisy GG, Taylor EW. The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J. Cell Biol. 1967;34:535–548. - PMC - PubMed

[5] Howard J, Hudspeth AJ, Vale RD. Movement of microtubules by single kinesin molecules. Nature. 1989;342:154–158. - PubMed

[6] Howard J, Hudspeth AJ, Vale RD. Movement of microtubules by single kinesin molecules. Nature. 1989;342:154–158. - PubMed

[7] Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993;365:721–727. - PubMed

[8] Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993;365:721–727. - PubMed

[9] Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984;312:237–242. - PubMed

[10] Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984;312:237–242. - PubMed

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Microtubules: 50 years on from the discovery of tubulin

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Microtubules: 50 years on from the discovery of tubulin

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